Glutamine protects the small intestinal mucosa in anticancer drug-induced rat enteritis model

• Material Type: 博士論文
• Title: Glutamine protects the small intestinal mucosa in anticancer drug-induced rat enteritis model
• Author/Editor: Takechi, Hirokazu; Mawatari, Kazuaki; Harada, Nagakatsu; Takahashi, Akira; Nakaya, Yutaka; Asakura, Megumi; Nakahashi, Mutsumi; Takizawa, Hiromitsu; Goto, Masakazu; Nishino, Takeshi; Minato, Takuya; Furukita, Yoshihito; Yamamoto, Yota; Yuasa, Yasuhiro; Yamai, Hiromichi; Yoshida, Takahiro; Seike, Junichi; Tangoku, Akira
• Author Heading: Takechi, Hirokazu; Mawatari, Kazuaki; Harada, Nagakatsu; Takahashi, Akira; Nakaya, Yutaka; Asakura, Megumi; Nakahashi, Mutsumi; Takizawa, Hiromitsu; Goto, Masakazu; Nishino, Takeshi; Minato, Takuya; Furukita, Yoshihito; Yamamoto, Yota; Yuasa, Yasuhiro; Yamai, Hiromichi; Yoshida, Takahiro; Seike, Junichi; Tangoku, Akira
• Publication Date: 2014-02
• Publication Date (W3CDTF): 2014-02
• Alternative Title: グルタミンは抗癌剤起因性腸炎モデルラットの小腸粘膜を保護する; Glutamine protects small intestinal mucosa
• Periodical title: The journal of medical investigation : JMI
• No. or year of volume/issue: 61 1-2
• Volume: 61
• Issue: 1-2
• Pages: 59-64
• ISSN (Periodical Title): ISSN : 1343-1420
• Degree grantor/type: 徳島大学
• Date Granted: 2014-03-19
• Dissertation Number: 甲第2742号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: glutamine; gastrointestinal toxity; anticancer drug; diamine oxidase; IgA
• Target Audience: 一般
• Note (General): Supportive therapy during chemotherapy has become essential, but effective preventive therapies to gastrointestinal mucosal injury are few. We investigated the efficacy of glutamine in rat anticancer drug-induced enteritis model. In this study, we used twenty male SD rats. They were divided into control, 5-fluorouracil (5-FU) (orally administered at 20mg/kg day), 5-FU+glutamine (1000 mg/kg/day) and 5-FU+glutamine+fiber and oligosaccharide (GFO[○R]) (1000 mg/kg/day) groups. All groups were sacrificed on day 6 and upper jejunums were excised. The jejunal villous height was measured in specimens. IgA level in jejunal washing solution, and serum diamine oxidase activity were also measured. The jejunal villous height was recognized as shorter in the specimen from 5-FU treated rats compared with 5-FU+glutamine treated rats (p<0.001). Serum diamine oxidase activity in 5-FU+glutamine group were significantly superior to that in 5-FU group (p=0.028). IgA level in jejunal washing solution tended to be higher in 5-FU+glutamine group than that in 5-FU group (p=0.076). On the other hand, serum diamine oxidase activity and IgA level in jejunal washing solution showed no significant difference between 5-FU+GFO and 5-FU treatment group. Our results suggest that glutamine showed protective effects on mucosal injury of small intestine in rat anticancer drug-induced enteritis model.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.2152/jmi.61.59
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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