Diagnosis of brain tumors using dynamic contrast-enhanced perfusion imaging with a short acquisition time

• Material Type: 博士論文
• Title: Diagnosis of brain tumors using dynamic contrast-enhanced perfusion imaging with a short acquisition time
• Author/Editor: Abe, Takashi; Mizobuchi, Yoshifumi; Nakajima, Kohhei; Otomi, Yoichi; Irahara, Saho; Obama, Yuki; Majigsuren, Mungunkhuyag; Khashbat, Delgerdalai; Kageji, Teruyoshi; Nagahiro, Shinji; Harada, Masafumi
• Author Heading: Abe, Takashi; Mizobuchi, Yoshifumi; Nakajima, Kohhei; Otomi, Yoichi; Irahara, Saho; Obama, Yuki; Majigsuren, Mungunkhuyag; Khashbat, Delgerdalai; Kageji, Teruyoshi; Nagahiro, Shinji; Harada, Masafumi
• Publication, Distribution, etc.: Springer
• Publication Date: 2015-02-24
• Publication Date (W3CDTF): 2015-02-24
• Alternative Title: 短時間の造影ダイナミック灌流画像を用いた脳腫瘍の質的診断について
• Periodical title: SpringerPlus
• No. or year of volume/issue: 4
• Volume: 4
• Pages: 88-
• ISSN (Periodical Title): ISSN : 2193-1801
• Degree grantor/type: 徳島大学
• Date Granted: 2016-03-23
• Dissertation Number: 甲第2898号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Magnetic resonance imaging (MRI); Dynamic contrast enhanced (DCE) perfusion; Brain tumor; Two-compartment model analysis; Pharmacokinetic model analysis
• Target Audience: 一般
• Note (General): This study sought to determine the diagnostic utility of perfusion parameters derived from dynamic contrast-enhanced (DCE) perfusion MRI with a short acquisition time (approximately 3.5 min) in patients with glioma, brain metastasis, and primary CNS lymphoma (PCNSL). Twenty-six patients with 29 lesions (4 low-grade glioma, 13 high-grade glioma, 7 metastasis, and 5 PCNSL) underwent DCE-MRI in a 3 T scanner. A ROI was placed on the hotspot of each tumor in maps for volume transfer contrast Ktrans, extravascular extracellular volume Ve, and fractional plasma volume Vp. We analyzed differences in parameters between tumors using the Mann–Whitney U test. We calculated sensitivity and specificity using receiver operating characteristics analysis. Mean K trans values of LGG, HGG, metastasis and PCNSL were 0.034, 0.31, 0.38, 0.44, respectively. Mean Ve values of each tumors was 0.036, 0.57, 0.47, 0.96, and mean Vp value of each tumors was 0.070, 0.086, 0.26, 0.17, respectively. Compared with other tumor types, low-grade glioma showed lower Ktrans (P < 0.01, sensitivity = 88%, specificity = 100%) and lower Ve (P < 0.01, sensitivity = 96%, specificity = 100%). PCNSL showed higher Ve (P < 0.01, sensitivity = 100%, specificity = 88%), but the other perfusion parameters overlapped with those of different histology. Kinetic parameters derived from DCE-MRI with short acquisition time provide useful information for the differential diagnosis of brain tumors.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Rights (production): Copyright: © 2015 Abe et al.; licensee Springer. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
• Related Material (DOI): 10.1186/s40064-015-0861-6
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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