Effects of Decreased Occlusal Loading during Growth on the Mandibular Bone Characteristics

• Material Type: 博士論文
• Title: Effects of Decreased Occlusal Loading during Growth on the Mandibular Bone Characteristics
• Author/Editor: Hichijo, Natsuko; Tanaka, Eiji; Kawai, Nobuhiko; Ruijven, Leo J. van; Langenbach, Geerling E. J.
• Author Heading: Hichijo, Natsuko; Tanaka, Eiji; Kawai, Nobuhiko; Ruijven, Leo J. van; Langenbach, Geerling E. J.
• Publication, Distribution, etc.: PLOS
• Publication Date: 2015-06-10
• Publication Date (W3CDTF): 2015-06-10
• Alternative Title: 成長期における咀嚼性刺激の減少が下顎骨の性状に及ぼす影響; Effects of Decreased Loading on the Mandible
• Periodical title: PLOS ONE
• No. or year of volume/issue: 10 6
• Volume: 10
• Issue: 6
• Pages: e0129290-
• ISSN (Periodical Title): ISSN : 1932-6203
• Degree grantor/type: 徳島大学
• Date Granted: 2016-03-23
• Dissertation Number: 甲第2939号
• Degree Type: 博士（歯学）
• Text Language Code: eng
• Subject Heading: muscle activity; loading stimulus; bone remodeling; mineralization
• Target Audience: 一般
• Note (General): Background Bone mass and mineralization are largely influenced by loading. The purpose of this study was to evaluate the reaction of the entire mandibular bone in response to decreased load during growth. It is hypothesized that decreased muscular loading will lead to bone changes as seen during disuse, i.e. loss of bone mass. Methods and Findings Ten 21-day-old Wistar strain male rats were divided into two groups (each n=5) and fed on either a hard- or soft-diet for 11 weeks. Micro-computed tomography was used for the investigation of bone mineralization, bone volume, bone volume fraction (BV/TV) and morphological analysis. Mandibular mineralization patterns were very consistent, showing a lower degree of mineralization in the ramus than in the corpus. In the soft-diet group, mineralization below the molars was significantly increased (p<0.05) compared to the hard diet group. Also, bone volume and BV/TV of the condyle and the masseter attachment were decreased in the soft-diet group (p<0.05). Morphological analysis showed inhibited growth of the ramus in the soft-diet group (p<0.05). Conclusion Decreased loading by a soft diet causes significant changes in the mandible. However, these changes are very region-specific, probably depending on the alterations in the local loading regime. The results suggest that muscle activity during growth is very important for bone quality and morphology.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Rights (production): Copyright: © 2015 Hichijo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
• Related Material (DOI): 10.1371/journal.pone.0129290
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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