Acceleration of tumor growth due to dysfunction in M1 macrophages and enhanced angiogenesis in an animal model of autoimmune disease

• Material Type: 博士論文
• Title: Acceleration of tumor growth due to dysfunction in M1 macrophages and enhanced angiogenesis in an animal model of autoimmune disease
• Author/Editor: Kondo, Tomoyuki; Tsunematsu, Takaaki; Yamada, Akiko; Arakaki, Rieko; Saito, Masako; Otsuka, Kunihiro; Kujiraoka, Satoko; Ushio, Aya; Kurosawa, Mie; Kudo, Yasusei; Ishimaru, Naozumi
• Author Heading: Kondo, Tomoyuki; Tsunematsu, Takaaki; Yamada, Akiko; Arakaki, Rieko; Saito, Masako; Otsuka, Kunihiro; Kujiraoka, Satoko; Ushio, Aya; Kurosawa, Mie; Kudo, Yasusei; Ishimaru, Naozumi
• Publication, Distribution, etc.: Springer nature
• Publication Date: 2016-01-25
• Publication Date (W3CDTF): 2016-01-25
• Alternative Title: 自己免疫疾患モデルにおけるM1マクロファージ不全と血管新生を介した腫瘍増殖の亢進; Cross-talk between autoimmunity and tumor immunity
• Periodical title: Laboratory Investigation
• No. or year of volume/issue: 96 4
• Volume: 96
• Issue: 4
• Pages: 468-480
• ISSN (Periodical Title): ISSN : 1530-0307
• Degree grantor/type: 徳島大学
• Date Granted: 2016-03-23
• Dissertation Number: 甲第2943号
• Degree Type: 博士（歯学）
• Text Language Code: eng
• Subject Heading: Autoimmunity; Cancer; Tumor associated macrophage; Angiogenesis; Tumor immunity
• Target Audience: 一般
• Note (General): Both autoimmunity and tumor immunity are immune responses against self-tissues or cells. However, the precise similarity or difference between them remains unclear. In this study, to understand a novel mechanism of tumor immunity, we performed transplantation experiments with a murine autoimmune model, C57BL/6J (B6)/lpr mice. A melanoma cell line, B16F10 cells, or granulocyte macrophage colony-stimulating factor- overexpressing B16F10 (B16F10/mGM) cells were transplanted into B6 or B6/lpr mice. Tumor growth by transplanted B16F10/mGM cells was significantly accelerated in B6/lpr mice compared with that in B6 mice. The accumulation of M1 macrophages in the tumor tissues of B6/lpr recipient mice was significantly lower compared with that in the control mice. In vitro co-culture experiment showed that impaired differentiation into M1 macrophages was observed in B6/lpr mice. The number of tumor vessels and vascular endothelial growth factor (VEGF) expression were also significantly enhanced in the tumor tissues of B6/lpr mice compared with those in the B6 mice. Moreover, VEGF expression was correlated with the increased expression of hypoxia-inducible factor-1α in the tumor tissues of B6/lpr mice. These results suggest that dysfunctional tumor immunity and enhanced angiogenesis in autoimmunity influence tumor growth.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Rights (production): This is the Author's Accepted Manuscript of the following article: Acceleration of tumor growth due to dysfunction in M1 macrophages and enhanced angiogenesis in an animal model of autoimmune disease, Tomoyuki Kondo, Takaaki Tsunematsu, Akiko Yamada, Rieko Arakaki, Masako Saito, Kunihiro Otsuka, Satoko Kujiraoka, Aya Ushio, Mie Kurosawa, Yasusei Kudo & Naozumi Ishimaru, Laboratory Investigation 96, 468-480 (2016), which has been published in final form at https://doi.org/10.1038/labinvest.2015.166.
• Related Material (DOI): 10.1038/labinvest.2015.166
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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http://repo.lib.tokushima-u.ac.jp/files/public/10/109707/20170929144128519695/LID201606141010.pdf fulltext

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