Effects of dietary phosphate on glucose and lipid metabolism

• Material Type: 博士論文
• Title: Effects of dietary phosphate on glucose and lipid metabolism
• Author/Editor: Abuduli, Maerjianghan; Ohminami, Hirokazu; Otani, Tamaki; Kubo, Hitoshi; Ueda, Haruka; Kawai, Yoshichika; Masuda, Masashi; Yamanaka-Okumura, Hisami; Sakaue, Hiroshi; Yamamoto, Hironori; Takeda, Eiji; Taketani, Yutaka
• Author Heading: Abuduli, Maerjianghan; Ohminami, Hirokazu; Otani, Tamaki; Kubo, Hitoshi; Ueda, Haruka; Kawai, Yoshichika; Masuda, Masashi; Yamanaka-Okumura, Hisami; Sakaue, Hiroshi; Yamamoto, Hironori; Takeda, Eiji; Taketani, Yutaka
• Publication, Distribution, etc.: The American Physiological Society
• Publication Date: 2016-01-19
• Publication Date (W3CDTF): 2016-01-19
• Alternative Title: 食事中のリンが糖代謝および脂質代謝における効果; PHOSPHATE REGULATES GLUCOSE AND LIPID METABOLISM
• Periodical title: American Journal of Physiology-Endocrinology and Metabolism
• No. or year of volume/issue: 310 7
• Volume: 310
• Issue: 7
• Pages: E526-E538
• ISSN (Periodical Title): ISSN : 0193-1849; ISSN : 1522-1555
• Degree grantor/type: 徳島大学
• Date Granted: 2016-09-29
• Dissertation Number: 甲第2993号
• Degree Type: 博士（栄養学）
• Text Language Code: eng
• Subject Heading: Brown adipose tissue; dietary phosphate; energy metabolism; visceral fat
• Target Audience: 一般
• Note (General): Recent epidemiological and animal studies have suggested that excess intake of phosphate (Pi) is a risk factor for the progression of chronic kidney disease and its cardiovascular complications. However, little is known about the impact of dietary high Pi intake on the development of metabolic disorders such as obesity and type 2 diabetes. In this study, we investigated the effects of dietary Pi on glucose and lipid metabolism in healthy rats. Male 8-wk-old Sprague-Dawley rats were divided into three groups and given experimental diets containing varying amounts of Pi, i.e., 0.2 [low Pi (LP)], 0.6 [control Pi (CP)], and 1.2% [high Pi (HP)]. After 4 wk, the HP group showed lower visceral fat accumulation compared with other groups, accompanied by a low respiratory exchange ratio (V˙ CO2/V˙ O2) without alteration of locomotive activity. The HP group had lower levels of plasma insulin and nonesterified fatty acids. In addition, the HP group also showed suppressed expression of hepatic lipogenic genes, including sterol regulatory element-binding protein-1c, fatty acid synthase, and acetyl-CoA carboxylase, whereas there was no difference in hepatic fat oxidation among the groups. On the other hand, uncoupling protein (UCP) 1 and peroxisome proliferator-activated receptor-γ coactivator-1α(PGC-1α) expression were significantly increased in the brown adipose tissue (BAT) of the HP group. Our data demonstrated that a high-Pi diet can negatively regulate lipid synthesis in the liver and increase mRNA expression related to lipid oxidation and UCP1 in BAT, thereby preventing visceral fat accumulation. Thus, dietary Pi is a novel metabolic regulator.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1152/ajpendo.00234.2015
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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