CSF cytokine profile distinguishes multifocal motor neuropathy from progressive muscular atrophy

• Material Type: 博士論文
• Title: CSF cytokine profile distinguishes multifocal motor neuropathy from progressive muscular atrophy
• Author/Editor: Furukawa, Takahiro; Matsui, Naoko; Fujita, Koji; Nodera, Hiroyuki; Shimizu, Fumitaka; Miyamoto, Katsuichi; Takahashi, Yukitoshi; Kanda, Takashi; Kusunoki, Susumu; Izumi, Yuishin; Kaji, Ryuji
• Author Heading: Furukawa, Takahiro; Matsui, Naoko; Fujita, Koji; Nodera, Hiroyuki; Shimizu, Fumitaka; Miyamoto, Katsuichi; Takahashi, Yukitoshi; Kanda, Takashi; Kusunoki, Susumu; Izumi, Yuishin; Kaji, Ryuji
• Publication, Distribution, etc.: American Academy of Neurology|Wolters Kluwer Health
• Publication Date: 2015-08-06
• Publication Date (W3CDTF): 2015-08-06
• Alternative Title: 髄液サイトカインプロファイルによる多巣性運動ニューロパチーと進行性筋萎縮症の鑑別
• Periodical title: Neurology : Neuroimmunology & Neuroinflammation
• No. or year of volume/issue: 2 5
• Volume: 2
• Issue: 5
• Pages: e138-
• ISSN (Periodical Title): ISSN : 2332-7812
• Degree grantor/type: 徳島大学
• Date Granted: 2016-10-27
• Dissertation Number: 甲第2998号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Amyotrophic lateral sclerosis; progressive muscular atrophy; multifocal motor neuropathy; cytokine; cerebrospinal fluid
• Target Audience: 一般
• Note (General): Objective: We aimed to compare the cytokine and chemokine profiles of patients with multifocal motor neuropathy (MMN) with those of patients with progressive muscular atrophy (PMA) and amyotrophic lateral sclerosis (ALS) to investigate immunologic differences in the CNS. Methods: CSF from 12 patients with MMN, 8 with PMA, 26 with sporadic ALS, and 10 with other noninflammatory neurologic disorders was analyzed for 27 cytokines and chemokines using the multiplex bead array assay. Cytokine titers of the 4 groups were compared, and correlations between the titers of relevant cytokines and clinical parameters were evaluated. Results: There were no obvious intrathecal changes except for interleukin (IL)-1 receptor antagonist in patients with MMN. In contrast, IL-4, IL-7, IL-17, eotaxin/CCL11, fibroblast growth factor- 2 (FGF-2), granulocyte colony-stimulating factor (G-CSF), and platelet-derived growth factor BB titers were significantly elevated in patients with PMA and ALS; of these, FGF-2 and G-CSF titers were elevated compared with those in patients with MMN. IL-4 and IL-10 titers were high in patients with ALS, particularly patients with possible ALS presenting with a slowly progressive course or mild symptoms. Conclusions: The CSF cytokine profile of patients with MMN is distinct from that of patients with PMA and ALS. The similarity of the cytokine profiles between patients with PMA and ALS suggests that PMA shares common immunologic features with ALS in the CNS, even without clinical evidence of upper motor neuron involvement.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Rights (production): Copyright: © 2015 American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
• Related Material (DOI): 10.1212/NXI.0000000000000138
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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