Site-specific elevation of interleukin-1β and matrix metalloproteinase-9 in the Willis circle by hemodynamic changes is associated with rupture in a novel rat cerebral aneurysm model

• Material Type: 博士論文
• Title: Site-specific elevation of interleukin-1β and matrix metalloproteinase-9 in the Willis circle by hemodynamic changes is associated with rupture in a novel rat cerebral aneurysm model
• Author/Editor: Miyamoto, Takeshi; Kung, David K.; Kitazato, Keiko T.; Yagi, Kenji; Shimada, Kenji; Tada, Yoshiteru; Korai, Masaaki; Kurashiki, Yoshitaka; Kinouchi, Tomoya; Kanematsu, Yasuhisa; Satomi, Junichiro; Hashimoto, Tomoki; Nagahiro, Shinji
• Author Heading: Miyamoto, Takeshi; Kung, David K.; Kitazato, Keiko T.; Yagi, Kenji; Shimada, Kenji; Tada, Yoshiteru; Korai, Masaaki; Kurashiki, Yoshitaka; Kinouchi, Tomoya; Kanematsu, Yasuhisa; Satomi, Junichiro; Hashimoto, Tomoki; Nagahiro, Shinji
• Publication, Distribution, etc.: International Society for Cerebral Blood Flow and Metabolism|Sage
• Publication Date: 2016-01-01
• Publication Date (W3CDTF): 2016-01-01
• Alternative Title: 新規脳動脈瘤ラットモデルにおける血行力学的変化によるウィリス動脈輪内の部位特異的なIL-1βとMMP-9の上昇は破裂に関連する; Rupture related to site-specific MMP-9 elevation
• Periodical title: Journal of Cerebral Blood Flow & Metabolism
• No. or year of volume/issue: 37 8
• Volume: 37
• Issue: 8
• Pages: 2795-2805
• ISSN (Periodical Title): ISSN : 1559-7016; ISSN : 0271-678X
• Degree grantor/type: 徳島大学
• Date Granted: 2017-03-23
• Dissertation Number: 甲第3005号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Animal Models; Cerebral Hemodynamics; Inflammation; Intracranial Aneurysm; Subarachnoid Hemorrhage
• Target Audience: 一般
• Note (General): The pathogenesis of subarachnoid hemorrhage (SAH)remains unclear. No models of cerebral aneurysms elicited solely by surgical procedures and diet have been established.Elsewhere we reported that only few rats in our original rat aneurysm model manifested rupture at the anterior-and posterior Willis circle (AW, PW) and thatmany harbored unruptured aneurysms at the anterior cerebral artery-olfactory artery bifurcation (ACA-OA). This suggests that rupture was site-specific. To test our hypothesis that a site-specific responseto hemodynamic changes is associated with aneurysmal rupture, we modified our original aneurysm model by altering the hemodynamics. During 90-day observation, the incidenceof ruptured aneurysms at the AW and PWwas significantly increasedand the high incidence of unruptured aneurysms at the ACA-OA persisted. This phenomenon was associatedwith an increase in the blood flow volume (BFVo). Notably, the level of matrix metalloproteinase(MMP)-9 associated with interleukin (IL)-1βwas augmented by the increase in the BFVo, suggesting that these molecules exacerbated the vulnerability of the aneurysmal wall. The current study first demonstrates that a site-specificincrease in IL-1β and MMP-9 elicited by hemodynamic changes is associated with rupture. Our novel rat model of rupture may help to developpharmaceutical approaches to prevent rupture.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1177/0271678X16675369
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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