(Pro)renin and (pro)renin receptor expression during kidney development in neonates

• Material Type: 博士論文
• Title: (Pro)renin and (pro)renin receptor expression during kidney development in neonates
• Author/Editor: Terada, Tomomasa; Urushihara, Maki; Saijo, Takahiko; Nakagawa, Ryuji; Kagami, Shoji
• Author Heading: Terada, Tomomasa; Urushihara, Maki; Saijo, Takahiko; Nakagawa, Ryuji; Kagami, Shoji
• Publication, Distribution, etc.: Springer Berlin Heidelberg
• Publication Date: 2016-12-19
• Publication Date (W3CDTF): 2016-12-19
• Alternative Title: 腎発生におけるプロレニン、プロレニン受容体の役割検討; Soluble (pro)renin receptor in neonates
• Periodical title: European Journal of Pediatrics
• No. or year of volume/issue: 176 2
• Volume: 176
• Issue: 2
• Pages: 183-189
• ISSN (Periodical Title): ISSN : 0340-6199; ISSN : 1432-1076
• Degree grantor/type: 徳島大学
• Date Granted: 2017-03-23
• Dissertation Number: 甲第3013号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Renin-angiotensin; Gestational age; Cord blood; Enzyme-linked immunosorbent assay; Immunohistochemistry
• Target Audience: 一般
• Note (General): Although a recent study demonstrated that the (pro)renin receptor ((P)RR) was highly expressed in the developing kidney during the mouse embryonic development, the mechanism by which (P)RR supports renal development in humans is not fully understood. In this study, we examined the plasma levels of (pro)renin and soluble (P)RR (s(P)RR) in cord blood and neonates as well as (P)RR expression in human kidney tissues. Samples were collected from 57 preterm and 67 full-term human neonates. (Pro)renin and s(P)RR levels were measured using enzyme-linked immunosorbent assays. Additionally, we performed an immunohistochemical (IHC) analysis of kidney tissues from neonates and minor glomerular abnormalities in order to assess (P)RR expression in the kidney. Plasma (pro)renin and s(P)RR levels in cord blood were significantly higher in preterm neonates than in full-term neonates. Four weeks after birth, these differences were no longer evident for either plasma (pro)renin or s(P)RR levels between the two groups. Importantly, plasma (pro)renin and s(P)RR levels in cord blood were inversely correlated with gestational age. Furthermore, IHC indicated that renal expression levels of (P)RR in neonates was stronger than that in minor glomerular abnormalities. Conclusion: (P)RR may play a pivotal role in prenatal renal development in humans.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1007/s00431-016-2820-9
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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https://repo.lib.tokushima-u.ac.jp/files/public/11/110037/20170929142254689017/LID201704131003.pdf fulltext

https://repo.lib.tokushima-u.ac.jp/files/public/11/110037/20171226104654612735/k3013_fulltext.pdf fulltext