Optical coherence tomographic parameters predictive of visual outcome after anti-VEGF therapy for retinal vein occlusion

• Material Type: 博士論文
• Title: Optical coherence tomographic parameters predictive of visual outcome after anti-VEGF therapy for retinal vein occlusion
• Author/Editor: Fujihara-Mino, Akiko; Mitamura, Yoshinori; Inomoto, Naoki; Sano, Hiroki; Akaiwa, Kei; Semba, Kentaro
• Author Heading: Fujihara-Mino, Akiko; Mitamura, Yoshinori; Inomoto, Naoki; Sano, Hiroki; Akaiwa, Kei; Semba, Kentaro
• Publication, Distribution, etc.: Dove Press
• Publication Date: 2016-07-18
• Publication Date (W3CDTF): 2016-07-18
• Alternative Title: 網膜静脈閉塞症に対する抗VEGF療法後の光干渉断層計を用いた視機能予後予測; OCT parameters and visual outcome in anti-VEGF therapy for RVO
• Periodical title: Clinical Ophthalmology
• No. or year of volume/issue: 10
• Volume: 10
• Pages: 1305-1313
• ISSN (Periodical Title): ISSN : 1177-5483
• Degree grantor/type: 徳島大学
• Date Granted: 2017-03-23
• Dissertation Number: 甲第3030号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: anti-VEGF therapy; retinal sensitivity; retinal vein occlusion; spectral-domain optical coherence tomography; visual acuity
• Target Audience: 一般
• Note (General): Purpose: To determine the optical coherence tomography (OCT) parameters that are predictive of visual outcome after anti-VEGF therapy for a retinal vein occlusion (RVO). Methods: Fifty-seven eyes with macular edema (ME) secondary to a central or branch RVO treated with bevacizumab or ranibizumab were studied. Spectral-domain OCT and microperim¬etry were performed before, 1, 3, and 6 months after the treatment and at the final visit. Central retinal thickness (CRT), macular volume (MV), integrity of the external limiting membrane (ELM), ellipsoid zone (EZ), and foveal bulge (FB), and photoreceptor outer segment (PROS) length were determined. Results: The mean follow-up period was 17.8±11.5 months. In 46 of the 57 eyes, a resolution of the ME was achieved. The pretreatment CRT and MV, presence of intact ELM, EZ, and FB, and PROS length at the time of ME resolution were significantly correlated with the best-corrected visual acuity and retinal sensitivity at the final visit (P＞0.050). Multiple regression analyses showed that the pretreatment MV had the highest correlation with the posttreatment best-corrected visual acuity and retinal sensitivity (P＞0.050). Conclusion: The CRT, MV, ELM, EZ, FB, and PROS length are predictive factors for the visual outcome after anti-VEGF therapy for RVO.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Rights (production): Copyright © 2016 Fujihara-Mino et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php)
• Related Material (DOI): 10.2147/OPTH.S110793
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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