Bone Ingrowth to Ti Fibre Knit Block with High Deformability

• Material Type: 博士論文
• Title: Bone Ingrowth to Ti Fibre Knit Block with High Deformability
• Author/Editor: Henmi, Yoko; Naito, Yoshihito; Jimbo, Ryo; Jinno, Yohei; Sekine, Kazumitsu; Hamada, Kenichi
• Author Heading: Henmi, Yoko; Naito, Yoshihito; Jimbo, Ryo; Jinno, Yohei; Sekine, Kazumitsu; Hamada, Kenichi
• Publication, Distribution, etc.: Journal of Oral & Maxillofacial Research
• Publication Date: 2016-12-28
• Publication Date (W3CDTF): 2016-12-28
• Alternative Title: 高い変形能を示すチタン繊維編物内部への骨成長
• Periodical title: Journal of Oral & Maxillofacial Research
• No. or year of volume/issue: 7 4
• Volume: 7
• Issue: 4
• Pages: e2-
• ISSN (Periodical Title): ISSN : 2029-283X
• Degree grantor/type: 徳島大学
• Date Granted: 2017-03-23
• Dissertation Number: 甲第3081号
• Degree Type: 博士（歯学）
• Text Language Code: eng
• Subject Heading: biocompatible materials; bone formation; bone substitutes; elastic modulus; histological techniques; titanium
• Target Audience: 一般
• Note (General): Objectives: The objective of this study is to develop a Ti fibre knit block without sintering, and to evaluate its deformability and new bone formation in vivo. Material and Methods: A Ti fibre with a diameter of 150 μm was knitted to fabricate a Ti mesh tube. The mesh tube was compressed in a metal mould to fabricate porous Ti fibre knit blocks with three different porosities of 88%, 69%, and 50%. The elastic modulus and deformability were evaluated using a compression test. The knit block was implanted into bone defects of a rabbit’s hind limb, and new bone formation was evaluated using micro computed tomography (micro-CT) analysis and histological analysis. Results: The knit blocks with 88% porosity showed excellent deformability, indicating potential appropriateness for bone defect filling. Although the porosities of the knit block were different, they indicated similar elastic modulus smaller than 1 GPa. The elastic modulus after deformation increased linearly as the applied compression stress increased. The micro-CT analysis indicated that in the block with 50% porosity new bone filled nearly all of the pore volume four weeks after implantation. In contrast, in the block with 88% porosity, new bone filled less than half of the pore volume even 12 weeks after implantation. The histological analysis also indicated new bone formation in the block. Conclusions: The titanium fibre knit block with high porosity is potentially appropriate for bone defect filling, indicating good bone ingrowth after porosity reduction with applied compression.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Rights (production): Copyright © Henmi Y, Naito Y, Jimbo R, Jinno Y, Sekine K, Hamada K. Published in the JOURNAL OF ORAL & MAXILLOFACIAL RESEARCH (http://www.ejomr.org), 28 December 2016. This is an open-access article, first published in the JOURNAL OF ORAL & MAXILLOFACIAL RESEARCH, distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License(https://creativecommons.org/licenses/by-nc-nd/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work and is properly cited. The copyright, license information and link to the original publication on (http://www.ejomr.org) must be included.
• Related Material (DOI): 10.5037/jomr.2016.7402
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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http://repo.lib.tokushima-u.ac.jp/files/public/11/110102/20170929142407346951/LID201704261011.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/110102/20170929142407667102/LID201704261012.pdf fulltext

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