嗅球におけるステロイド合成酵素の局在

Material type: 文書・図像類

Author: 清蔭, 恵美ほか

Publisher: 徳島医学会

Publication date: 2003-10-25

Material Format: Digital

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Note (General)：: Neurosteroids are synthesized through mechanism at least partly independent of the peripheral steroidogenic glands, and their neurobiological actions ...

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Material Type: 文書・図像類
Title: 嗅球におけるステロイド合成酵素の局在
Author/Editor: 清蔭, 恵美
樋田, 一徳
山本, 登志子
石村, 和敬
Author Heading: 清蔭, 恵美
樋田, 一徳
山本, 登志子
石村, 和敬
Publication, Distribution, etc.: 徳島医学会
Publication Date: 2003-10-25
Publication Date (W3CDTF): 2003-10-25
Alternative Title: Localization of steroid-synthesizing enzymes in the olfactory bulb
キュウキュウニオケルステロイドゴウセイコウソノキョクザイ
Periodical title: 四国医学雑誌
No. or year of volume/issue: 59 4-5
Volume: 59
Issue: 4-5
Pages: 250-251
ISSN (Periodical Title): ISSN : 0037-3699
Text Language Code: jpn
Subject Heading: neurosteroid
olfactory bulb
enzyme
steroid
immunohistochemistry
localization
Target Audience: 一般
Note (General): Neurosteroids are synthesized through mechanism at least partly independent of the peripheral steroidogenic glands, and their neurobiological actions seem to depend on the specific functions of various brain regions. However, little is known about neurosteroids function corresponding to specific structure and functions of the brain regions. Thus the present study analyzed localization of steroid-synthesizing enzymes in the rat and mouse olfactory bulb. RT-PCR and Western-blotting indicated the possible presence of almost all enzymes of steroid synthesis from cholesterol to estradiol, that is, cholesterol side chain cleavage enzyme (P450scc : cholesterol→pregnenolone), 3β-hydroxysteroid dehydrogenase/Δ5 - 4 isomerase (3β-HSD : pregnenolone→progesterone), 17α-hydroxylase/C17-C20lyase (P450c17 : progesterone→ androstenedione), 17β-hydroxysteroid dehydrogenase (17β-HSD : androstenedione→testosterone), 5α-reductase (5αR:testosterone→5α-dihydrotestosterone), and aromatase (testosterone→ estradiol). Immunohistochemistry confirmed that the 5α-reductase was mainly in glial cells with various immunoreactivity and co-localization pattern, but other enzymes were in bulbar neurons, and at least co-localized in mitral/tufted cells. In addition, so far analyzed, enzymatic activities of P450c17 (a key enzyme in sex steroid synthesis) and 17β-HSD were detected biochemically. These enzyme expression and activities were influenced under exposure of 17β-estradiol with various degrees. These findings indicated the presence of steroid-synthesizing activities, and thus of possible neurosteroid metabolism in the olfactory bulb.
Access Restrictions: 限定公開
Periodical Title (NCID): AN00102041
https://ci.nii.ac.jp/ncid/AN00102041
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ