EGFR Downregulation after Anti-EGFR Therapy Predicts the Antitumor Effect in Colorectal Cancer

• Material Type: 博士論文
• Title: EGFR Downregulation after Anti-EGFR Therapy Predicts the Antitumor Effect in Colorectal Cancer
• Author/Editor: Okada, Yasuyuki; Kimura, Tetsuo; Nakagawa, Tadahiko; Okamoto, Koichi; Fukuya, Akira; Goji, Takahiro; Fujimoto, Shota; Sogabe, Masahiro; Miyamoto, Hiroshi; Muguruma, Naoki; Tsuji, Yasushi; Okahisa, Toshiya; Takayama, Tetsuji
• Author Heading: Okada, Yasuyuki; Kimura, Tetsuo; Nakagawa, Tadahiko; Okamoto, Koichi; Fukuya, Akira; Goji, Takahiro; Fujimoto, Shota; Sogabe, Masahiro; Miyamoto, Hiroshi; Muguruma, Naoki; Tsuji, Yasushi; Okahisa, Toshiya; Takayama, Tetsuji
• Publication, Distribution, etc.: American Association for Cancer Research
• Publication Date: 2017-07-11
• Publication Date (W3CDTF): 2017-07-11
• Alternative Title: 大腸癌における抗EGFR抗体薬治療後のEGFR Downregulationは抗腫瘍効果を予測する; EGFR Down-regulation Predicts anti-EGFR Response
• Periodical title: Molecular Cancer Research
• No. or year of volume/issue: 15 10
• Volume: 15
• Issue: 10
• Pages: 1445-1454
• ISSN (Periodical Title): ISSN : 1541-7786; ISSN : 1557-3125
• Degree grantor/type: 徳島大学
• Date Granted: 2017-10-26
• Dissertation Number: 甲第3116号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Colorectal cancer; EGFR; cetuximab; internalization; degradation
• Target Audience: 一般
• Note (General): ABC, antibody-binding capacity; ADCC, antibody-dependent cellular cytotoxicity; ATCC, American Type Culture Collection; BSA, bovine serum albumin; CR, complete response; CRC, colorectal cancer; CT, computed tomography; ECACC, European Collection of Authenticated Cell Cultures; EGF, epidermal growth factor; EGFR, epidermal growth factor receptor; ETS, early tumor shrinkage; FBS, fetal bovine serum; FISH, fluorescent in situ hybridization; HRP, horseradish peroxidase; HSRRB, Health Science Research Resources Bank; IHC, immunohistochemistry; MesNa, Mercaptoethanesulfonic acid sodium; mCRC, metastatic colorectal cancer; mAb, monoclonal antibody; mAbs, monoclonal antibodies; PARP, poly (ADP-ribose) polymerase; PBS, phosphate buffered saline; PD, progressive disease; p-ERK, phosphorylated ERK; PNA-LNA, peptide nucleic acid-locked nucleic acid; PR, partial response; PVDF, polyvinylidene difluoride; RECIST, Response Evaluation Criteria in Solid Tumors; RIKEN BRC, RIKEN BioResource Center; SD, stable disease; SDS, sodium dodecyl sulfate; SDS-PAGE, SDS-polyamide gel electrophoresis; TBS-T, Tris-buffered saline with 0.1% Tween; TGF-α, transforming growth factor-α.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1158/1541-7786.MCR-16-0383
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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http://repo.lib.tokushima-u.ac.jp/files/public/11/110960/20171206093953462138/k3116_abstract_review.pdf fulltext

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