Role of thrombospondin-1 expression in colorectal liver metastasis and its molecular mechanism

• Material Type: 博士論文
• Title: Role of thrombospondin-1 expression in colorectal liver metastasis and its molecular mechanism
• Author/Editor: Teraoku, Hiroki; Morine, Yuji; Ikemoto, Tetsuya; Saito, Yu; Yamada, Shinichiro; Yoshikawa, Masato; Takasu, Chie; Higashijima, Jun; Imura, Satoru; Shimada, Mitsuo
• Author Heading: Teraoku, Hiroki; Morine, Yuji; Ikemoto, Tetsuya; Saito, Yu; Yamada, Shinichiro; Yoshikawa, Masato; Takasu, Chie; Higashijima, Jun; Imura, Satoru; Shimada, Mitsuo
• Publication, Distribution, etc.: Japanese Society of Hepato‐Biliary‐Pancreatic Surgery|Wily
• Publication Date: 2016-07-12
• Publication Date (W3CDTF): 2016-07-12
• Alternative Title: 大腸癌肝転移におけるThrombospondin-1発現の役割とその分子メカニズム
• Periodical title: Journal of Hepato-Biliary-Pancreatic Sciences
• No. or year of volume/issue: 23 9
• Volume: 23
• Issue: 9
• Pages: 565-573
• ISSN (Periodical Title): ISSN : 1868-6974; ISSN : 1868-6982
• Degree grantor/type: 徳島大学
• Date Granted: 2017-10-26
• Dissertation Number: 甲第3118号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: 大腸癌; 肝転移; THBS-1; HIF-1; EMT; Thrombospondin-1; colorectal liver metastasis; immunohistochemistry
• Target Audience: 一般
• Note (General): Background/Purpose Thrombospondin-1 (THBS-1), a glycoprotein, is an endogenous inhibitor of angiogenesis and tumor growth. In this study, we investigated the clinical role and mechanism of THBS-1 expression in colorectal liver metastases, focusing on the relationships between its expression and tumor growth, epithelial–mesenchymal transition (EMT), and expression of other relevant molecules. Methods Ninety-four patients who initially underwent curative hepatic resection were enrolled in this study and correlations between expression of THBS-1 (THBS-1 high [n=35] and THBS-1 low [n=59]) and tumor growth, Ki-67 labelling index (Ki-67 LI), expression of other relevant molecules, and microvessel density (MVD) investigated. Results THBS1 low expression correlated with more advanced grade of liver and lymph node metastases and significantly worse overall survival than strong THBS1 expression (3-year survival: 96.7% vs. 65.4%, p<0.01). Multivariate analysis identified THBS1 low expression as an independent prognostic factor (HR=2.82, 95% CI=1.21–7.71, p=0.01). THBS-1 low expression correlated positively with high Ki-67 LI (p<0.05) and inversely with E-cadherin (p<0.05) and hypoxia inducible factor-1α (HIF-1α) expression (p<0.05); THBS-1 expression and MVD were not significantly correlated. Conclusions Low THBS-1 expression may be an independent poor prognostic factor that affects tumor growth and EMT acquisition. Additionally, THBS-1 may be regulated by the HIF-1 pathway.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1002/jhbp.376
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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