The essential role of luminal BK channels in distal colonic K+ secretion

Material type: 文書・図像類

Author: Sörensen, Mads Vほか

Publisher: Faculty of Medicine Tokushima University

Publication date: 2009-12

Material Format: Digital

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Note (General)：: Distal colonic K+ excretion is determined by the balance of K+ absorption and K+ secretion of the enterocytes. K+ secretion occurs via active basolate...

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Material Type: 文書・図像類
Title: The essential role of luminal BK channels in distal colonic K+ secretion
Author/Editor: Sörensen, Mads V
Leipziger, Jens
Author Heading: Sörensen, Mads V
Leipziger, Jens
Publication, Distribution, etc.: Faculty of Medicine Tokushima University
Publication Date: 2009-12
Publication Date (W3CDTF): 2009-12
Periodical title: The Journal of Medical Investigation
No. or year of volume/issue: 56 Supplement
Volume: 56
Issue: Supplement
Pages: 301-301
ISSN (Periodical Title): ISSN : 1349-6867
ISSN : 1343-1420
Text Language Code: eng
Subject Heading: K+ channel
ion secretion
colon
epithelium
Target Audience: 一般
Note (General): Distal colonic K+ excretion is determined by the balance of K+ absorption and K+ secretion of the enterocytes. K+ secretion occurs via active basolateral K+ uptake mostly via the NKCC1 co-transporter followed by K+ exit via a luminal K+ channel. The specific focus here is directed towards the luminal secretory K+ channel (1). Several recent observations highlight the pivotal role of the large conductance, Ca2+-activated KCa1.1 (BK, KCNMA) channel as the only functionally relevant luminal K+ efflux pathway in mouse distal colon (2, 3). This conclusion was based on defining results from BK knock-out mice. The following key observations were made : 1. BK channels mediate the resting distal colonic K+ secretion (2, 4), 2. They are acutely stimulated by activation of luminal nucleotide receptor and elevations of intracellular Ca2+ (2, 4, 5), 3. Colonic BK channels are up-regulated by increases of plasma aldosterone (3), 4. In addition, the cAMP-stimulated distal colonic K+ secretion is apparently mediated via BK channels, 5. Finally, aldosterone was found to up-regulate specifically the ZERO (e.g. cAMP activated) C-terminal splice variant of the BK channel. In summary, we suggest that the sole exit pathway for transcellular K+ secretion in mammalian distal colon is the BK channel, which is the target for short term intracellular Ca2+ and cAMP activation and long term aldosterone regulation.
Format (IMT): application/pdf
Source: http://repo.lib.tokushima-u.ac.jp/files/public/11/111358/20180406110204782768/jmi_56_suppl_301.pdf
http://repo.lib.tokushima-u.ac.jp/files/public/11/111358/20180406110204782768/jmi_56_suppl_301.pdf
Access Restrictions: 限定公開
Related Material (DOI): 10.2152/jmi.56.301
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ