Negative perception of socioeconomic status with depressive mood down-regulates expression of PPBP and SLC1A7 genes in peripheral blood leukocytes

• Material Type: 博士論文
• Title: Negative perception of socioeconomic status with depressive mood down-regulates expression of PPBP and SLC1A7 genes in peripheral blood leukocytes
• Author/Editor: Fujita, Kinuyo; Kuwano, Yuki; Saijo, Saki; Nishikawa, Tatsuya; Nishida, Kensei; Rokutan, Kazuhito
• Author Heading: Fujita, Kinuyo; Kuwano, Yuki; Saijo, Saki; Nishikawa, Tatsuya; Nishida, Kensei; Rokutan, Kazuhito
• Publication, Distribution, etc.: Cogent OA
• Publication Date: 2017-06-14
• Publication Date (W3CDTF): 2017-06-14
• Alternative Title: 社会経済的格差のネガティブな認識と抑うつ気分は末梢血白血球のPPBPとSLC1A7 遺伝子の発現を低下させる
• Periodical title: Cogent Psychology
• No. or year of volume/issue: 4
• Volume: 4
• Pages: 1338825-
• ISSN (Periodical Title): ISSN : 2331-1908
• Degree grantor/type: 徳島大学
• Date Granted: 2018-03-23
• Dissertation Number: 甲第3129号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: subjective socioeconomic status; depressive mood; peripheral blood leukocytes; gene expression; PPBP; SLC1A7
• Target Audience: 一般
• Note (General): Inequality in socioeconomic status (SES) is associated with an increased risk for the development of mental health problems. Here, we examined the association between socioeconomic status (SSS) and psychological distress, and measured gene expression signatures in peripheral blood leukocytes responsible for this association, in 129 healthy adults (27 males and 102 females, aged 44.0 ± 13.0 years) working in a private hospital in Japan. Depressive mood was assessed by Zung Selfrating Depression Scale (SDS). A multiple regression analysis adjusted for gender and age showed that subjective SSS was independently and negatively associated with SDS score. We next focused on 9 subjects who exhibited low SSS scores and 11 subjects with high SSS scores. Microarray analysis revealed that levels of 522 mRNAs were differentially expressed in periheral leukocytes between low and high-SSS groups. The differentially expressed genes were preferentially involved in cellular movement or inflammatory responses. Among them, mRNA levels of pro-platelet basic protein (PPBP) and solute carrier family 1 (glutamine transporter), member 7 (SLC1A7) were negatively correlated with SSS scores. Our results re-confirmed the association between negative perception of SES and depressive mood in healthy adults, and suggest a possible involvement of PPBP and SLC1A7 in the association.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Rights (production): © 2017 The Author(s). This open access article is distributed under a Creative Commons Attribution (CC-BY) 4.0 license.
• Related Material (DOI): 10.1080/23311908.2017.1338825
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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