High phosphate diet suppresses lipogenesis in white adipose tissue

• Material Type: 博士論文
• Title: High phosphate diet suppresses lipogenesis in white adipose tissue
• Author/Editor: Imi, Yukiko; Yabiki, Norie; Abuduli, Maerjianghan; Masuda, Masashi; Yamanaka-Okumura, Hisami; Taketani, Yutaka
• Author Heading: Imi, Yukiko; Yabiki, Norie; Abuduli, Maerjianghan; Masuda, Masashi; Yamanaka-Okumura, Hisami; Taketani, Yutaka
• Publication, Distribution, etc.: SOCIETY FOR FREE RADICAL RESEARCH JAPAN
• Publication Date: 2018-11-01
• Publication Date (W3CDTF): 2018-11-01
• Alternative Title: 高リン食は白色脂肪組織の脂肪合成を抑制する
• Periodical title: Journal of Clinical Biochemistry and Nutrition
• No. or year of volume/issue: 63 3
• Volume: 63
• Issue: 3
• Pages: 181-191
• ISSN (Periodical Title): ISSN : 1880-5086; ISSN : 0912-0009
• Degree grantor/type: 徳島大学
• Date Granted: 2018-03-23
• Dissertation Number: 甲第3150号
• Degree Type: 博士（栄養学）
• Text Language Code: eng
• Subject Heading: dietary phosphate; white adipose tissue; insulin; lipogenesis; lipolysis
• Target Audience: 一般
• Note (General): Excessive phosphate intake has been positively associated with renal and vascular dysfunction, conversely negatively associated with body fat accumulation. We investigated the effect of a high-phosphate diet on the expression of lipid metabolic genes in white adipose tissue and liver. Male 8-week-old Sprague–Dawley rats were fed a control diet containing 0.6% phosphate or a high-phosphate diet containing 1.5% phosphate for 4 weeks. In comparison to the control group, the HP group showed a significantly lower body fat mass and fasting plasma insulin level alongside decreased lipogenic and increased lipolytic gene expression in visceral fat. Additionally, the expression of genes involved in hepatic lipogenesis, hepatic glycogenesis, and triglyceride accumulation decreased in the high-phosphate group. Exogenous phosphate, parathyroid hormone, and fibroblast growth factor 23 did not directly affect the expression of lipolytic or lipogenic genes in 3T3-L1 adipocytes and HepG2 hepatocytes. Thus, the high-phosphate diet suppressed the activity of white adipose tissue by increasing lipolytic gene expression and decreasing lipogenic gene expression. These effects could have been caused by the lowered fasting plasma insulin level that occurred in response to the high-phosphate diet, but were not directly caused by the increases in plasma phosphate or phosphaturic hormones.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Rights (production): © 2018 Society for Free Radical Research Japan
• Related Material (DOI): 10.3164/jcbn.17-141
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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