APOB codon 4311 polymorphism is associated with hepatitis C virus infection through altered lipid metabolism

• Material Type: 博士論文
• Title: APOB codon 4311 polymorphism is associated with hepatitis C virus infection through altered lipid metabolism
• Author/Editor: Harada, Rie; Kimura, Masako; Sato, Yasushi; Taniguchi, Tatsuya; Tomonari, Tetsu; Tanaka, Takahiro; Tanaka, Hironori; Muguruma, Naoki; Shinomiya, Hirohiko; Honda, Hirohito; Imoto, Issei; Sogabe, Masahiro; Okahisa, Toshiya; Takayama, Tetsuji
• Author Heading: Harada, Rie; Kimura, Masako; Sato, Yasushi; Taniguchi, Tatsuya; Tomonari, Tetsu; Tanaka, Takahiro; Tanaka, Hironori; Muguruma, Naoki; Shinomiya, Hirohiko; Honda, Hirohito; Imoto, Issei; Sogabe, Masahiro; Okahisa, Toshiya; Takayama, Tetsuji
• Publication, Distribution, etc.: Springer Nature|BioMed Central
• Publication Date: 2018-01-30
• Publication Date (W3CDTF): 2018-01-30
• Alternative Title: APOBコドン4311遺伝子多型は脂質代謝を変化させることによりC型肝炎ウイルスの感染性に関与する
• Periodical title: BMC Gastroenterology
• No. or year of volume/issue: 18
• Volume: 18
• Pages: 24-
• ISSN (Periodical Title): ISSN : 1471-230X
• Degree grantor/type: 徳島大学
• Date Granted: 2018-05-24
• Dissertation Number: 甲第3198号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Hepatitis C virus; Lipid metabolism; SNPs; ApoB
• Target Audience: 一般
• Note (General): Background: It has been reported that some single-nucleotide polymorphisms (SNPs) in lipid regulators such as apolipoproteins and cell surface molecules for hepatitis C virus (HCV) entry into hepatocytes are associated with HCV infection. However, it is unknown how HCV infection is affected by altered lipid metabolism resulting from the SNPs. We investigated the relationship between these SNPs and HCV infection status, and also analyzed the mechanism by which these SNPs mediate HCV infection via lipid metabolism alterations. Methods: Serum lipid and apolipoprotein profiles were tested in 158 HCV-positive and 220 HCV-negative subjects. We selected 22 SNPs in five lipid regulator genes which were related to HCV entry into hepatocytes and to lipid metabolism (APOA1, APOB, SR-B1, LDLR, and APOE), and their polymorphisms were analyzed using the PCR-sequencespecific oligonucleotide probe-Luminex method. Results: An APOB N4311S (g.41553a > g) SNP, rs1042034, was significantly associated with HCV positivity; the HCV positivity rate for the minor allele AA genotype was significantly higher than for genotype AG + GG (P = 0.016). Other SNPs except for APOB P2712L SNP rs676210, which is in linkage disequilibrium with rs1042034, showed no significant difference in genotype distribution. The serum level of low density lipoprotein-cholesterol (LDL-C) in the genotype AA group was significantly lower than in the genotype non-AA group (P = 0.032), whereas the triglyceride (TG) level was significantly higher (P = 0.007). Conclusion: An APOB SNP, rs1042034, is closely associated with HCV infection through lipid metabolism alteration. The minor allele AA genotype might contribute to facilitating serum LDL uptake into hepatocytes via LDLR by modifying their affinity and interaction and may have an influence on HCV infection by their entry to the liver through the LDLR.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Rights (production): © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
• Related Material (DOI): 10.1186/s12876-018-0747-5
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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