Intratumoral evaluation of 3D microvasculature and nanoparticle distribution using a gadolinium-dendron modified nano-liposomal contrast agent with magnetic resonance micro-imaging

• Material Type: 博士論文
• Title: Intratumoral evaluation of 3D microvasculature and nanoparticle distribution using a gadolinium-dendron modified nano-liposomal contrast agent with magnetic resonance micro-imaging
• Author/Editor: Nitta, Nobuhiro; Takakusagi, Yoichi; Kokuryo, Daisuke; Shibata, Sayaka; Tomita, Akihiro; Higashi, Tatsuya; Aoki, Ichio; Harada, Masafumi
• Author Heading: Nitta, Nobuhiro; Takakusagi, Yoichi; Kokuryo, Daisuke; Shibata, Sayaka; Tomita, Akihiro; Higashi, Tatsuya; Aoki, Ichio; Harada, Masafumi
• Publication, Distribution, etc.: Elsevier
• Publication Date: 2018-04-04
• Publication Date (W3CDTF): 2018-04-04
• Alternative Title: MRマイクロイメージングとガドリニウム-デンドロン修飾ナノリポソーム造影剤を用いた3D微小血管およびナノ粒子分布の腫瘍内評価
• Periodical title: Nanomedicine : Nanotechnology, Biology and Medicine
• No. or year of volume/issue: 14 4
• Volume: 14
• Issue: 4
• Pages: 1315-1324
• ISSN (Periodical Title): ISSN : 1549-9634
• Degree grantor/type: 徳島大学
• Date Granted: 2018-05-24
• Dissertation Number: 甲第3200号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: liposomal contrast agent; tumor heterogeneity; angiography; MRI; EPR
• Target Audience: 一般
• Note (General): The enhanced permeability and retention (EPR) effect is variable depending on nanoparticle properties and tumor/vessel conditions. Thus, intratumoral evaluations of the vasculature and nanoparticle distribution are important for predicting the therapeutic efficacy and the intractability of tumors. We aimed to develop a tumor vasculature evaluation method and high-resolution nanoparticle delivery imaging using magnetic resonance (MR) micro-imaging technology with a gadolinium (Gd)-dendron assembled liposomal contrast agent. Using the Gd-liposome and a cryogenic receiving coil, we achieved 50-μm isotropic MR angiography with clear visualization of tumor micro-vessel structure. The Gd-liposome-enhanced MR micro-imaging revealed differences in the vascular structures between Colon26- and SU-DHL6-grafted mice models. The vessel volumes and diameters measured for both tumors were significantly correlated with histological observations. The MR micro-imaging methods facilitate the evaluation of intratumoral vascularization patterns, the quantitative assessment of vascular-properties that alter tumor malignancy, particle retentivity, and the effects of treatment.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Rights (production): © 2018 . Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license ( https://creativecommons.org/licenses/by-nc-nd/4.0/ )
• Related Material (DOI): 10.1016/j.nano.2018.03.006
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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