Detection of aberrant crypt foci with image-enhanced endoscopy

• Material Type: 博士論文
• Title: Detection of aberrant crypt foci with image-enhanced endoscopy
• Author/Editor: Kagemoto, Kaizo; Okamoto, Koichi; Takaoka, Toshi; Sato, Yasushi; Kitamura, Shinji; Kimura, Tetsuo; Sogabe, Masahiro; Miyamoto, Hiroshi; Muguruma, Naoki; Tsuneyama, Koichi; Takayama, Tetsuji
• Author Heading: Kagemoto, Kaizo; Okamoto, Koichi; Takaoka, Toshi; Sato, Yasushi; Kitamura, Shinji; Kimura, Tetsuo; Sogabe, Masahiro; Miyamoto, Hiroshi; Muguruma, Naoki; Tsuneyama, Koichi; Takayama, Tetsuji
• Publication, Distribution, etc.: Georg Thieme Verlag KG Stuttgart
• Publication Date: 2018-08-01
• Publication Date (W3CDTF): 2018-08-01
• Alternative Title: 画像強調内視鏡を用いたaberrant crypt fociの観察
• Periodical title: Endoscopy International Open
• No. or year of volume/issue: 6 8
• Volume: 6
• Issue: 8
• Pages: E924-E933
• ISSN (Periodical Title): ISSN : 2196-9736
• Degree grantor/type: 徳島大学
• Date Granted: 2018-07-26
• Dissertation Number: 甲第3203号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: ACF; NBI; BLI; IEE; Colorectal cancer
• Target Audience: 一般
• Note (General): Background and study aims Conventional detection of aberrant crypt foci (ACF) with dye-spraying and magnifying observation is labor- and skill-intensive. We performed a prospective non-inferiority study to investigate the utility of image-enhanced endoscopy (IEE) for detection of ACF. Patients and methods Patients with a history of colorectal neoplasm were eligible. The number of ACF in the lower rectum was counted first using IEE magnification with narrow- band imaging (NBI) or blue-laser imaging (BLI), and subsequently using the methylene blue method. The primary endpoint was the ACF detection rate with IEE, i. e., the number of ACF detected with IEE relative to the number of ACF detected with methylene blue. The secondary endpoints were bowel preparation time, ACF detection time, and the detection rate with NBI or BLI. Results A total of 40 patients were enrolled (NBI 20 and BLI 20). The overall detection rate for ACF with IEE was 81.7% (503/616; 95%CI 78.8 – 84.6%), meeting the primary endpoint. The detection rate for ACF with BLI (84.9 %, 258/304) was significantly higher than with NBI (78.5%, 245/312; P < 0.05). Both bowel preparation time and ACF detection time were significantly shorter with IEE versus the methylene blue method (P < 0.01, respectively). The detection rates for dysplastic and non-dysplastic ACF with IEE were 84.4% (27/32) and 80.3% (469/584), respectively. Conclusion IEE is able to detect ACF during colonoscopy with sensitivity non-inferior to that of the conventional methylene blue method. IEE is simpler than the methylene blue method and is therefore a potentially useful new tool for ACF detection.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Rights (production): ©2018 Georg Thieme Verlag KG Stuttgart · New York This article under License of Creative Commons Attribution 4.0 License. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ )
• Related Material (DOI): 10.1055/a-0621-8794
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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