Elevated Preoperative Serum CEA Levels Is Associated with Poor Prognosis in Patients with Hepatocellular Carcinoma Through the Epithelial-Mesenchymal Transition

• Material Type: 博士論文
• Title: Elevated Preoperative Serum CEA Levels Is Associated with Poor Prognosis in Patients with Hepatocellular Carcinoma Through the Epithelial-Mesenchymal Transition
• Author/Editor: Yoshikawa, Masato; Morine, Yuji; Ikemoto, Tetsuya; Imura, Satoru; Higashijima, Jun; Iwahashi, Shuichi; Saito, Yu; Takasu, Chie; Yamada, Shinichiro; Ishikawa, Daichi; Teraoku, Hiroki; Takata, Atsushi; Yoshimoto, Toshiaki; Shimada, Mitsuo
• Author Heading: Yoshikawa, Masato; Morine, Yuji; Ikemoto, Tetsuya; Imura, Satoru; Higashijima, Jun; Iwahashi, Shuichi; Saito, Yu; Takasu, Chie; Yamada, Shinichiro; Ishikawa, Daichi; Teraoku, Hiroki; Takata, Atsushi; Yoshimoto, Toshiaki; Shimada, Mitsuo
• Publication, Distribution, etc.: International Institute of Anticancer Research
• Publication Date: 2017-03-01
• Publication Date (W3CDTF): 2017-03-01
• Alternative Title: 肝細胞癌患者における術前血清CEA値上昇は上皮間葉転換を介して予後不良と関連する; Elevated Preoperative Serum CEA Level Is with Hepatocellular Carcinoma with Poor Prognosis Through the Epithelial-Mesenchymal Transition
• Periodical title: Anticancer Research
• No. or year of volume/issue: 37 3
• Volume: 37
• Issue: 3
• Pages: 1169-1175
• ISSN (Periodical Title): ISSN : 0250-7005; ISSN : 1791-7530
• Degree grantor/type: 徳島大学
• Date Granted: 2018-07-26
• Dissertation Number: 甲第3204号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: CEA; CEACAM; epithelial mesenchymal transition; hepatocellular carcinoma
• Target Audience: 一般
• Note (General): Background: Serum carcinoembryonic antigen (CEA) is used as an indicator of tumor progression in a variety of carcinomas. A subset of patients with hepatocellular carcinoma (HCC) exhibit increased serum CEA level, but the significance of this is unclear. In this study, we investigated the prognosis of patients with HCC with increased serum CEA, and explored the correlations with expression of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) and epithelial–mesenchymal transition (EMT) and tumor angiogenesis. Materials and Methods: One hundred and twenty-three patients with HCC who underwent radical resection were divided into two groups according to a cut-off value of 5.0 ng/ml for serum CEA: high (n=24) and normal (n=99) groups. We compared the clinicopathological factors with serum CEA levels and its correlations with CEACAM1 expression, EMT-related factors and microvessel density (MVD) of tumor tissues by immunohistochemistry. Results: In the high CEA group, the disease-free survival (DFS) rate was significantly worse than in the normal CEA group. Multivariate analysis revealed that a high CEA level was an independent factor predictive of recurrence. Furthermore, increased serum CEA levels were positively correlated with CEACAM1 expression. Moreover, CEACAM1 expression was positively correlated with expression of EMT-related factors and MVD of tumor tissues. Conclusion: Increased serum CEA level reflected CEACAM1 expression and was an independent factor predictive of recurrence in HCC through EMT and tumor angiogenesis.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.21873/anticanres.11430
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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https://repo.lib.tokushima-u.ac.jp/files/public/11/112034/2018080910113462528/k3204_review_abstract.pdf fulltext

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