抗精神病薬服用者における女性化乳房・乳汁分泌についての検討

Material type: 文書・図像類

Author: 兼田, 康宏ほか

Publisher: 徳島医学会

Publication date: 1999-12-25

Material Format: Digital

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Note (General)：: Gynecomastia is known to be a side effect of neuroleptics. The authors investigated the prevalence of gynecomastia and galactorrhea in a group of regu...

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Material Type: 文書・図像類
Title: 抗精神病薬服用者における女性化乳房・乳汁分泌についての検討
Author/Editor: 兼田, 康宏
藤井, 哲
山岡, 孝
森本, 忠興
永峰, 勲
Author Heading: 兼田, 康宏
藤井, 哲
山岡, 孝
森本, 忠興
永峰, 勲
Publication, Distribution, etc.: 徳島医学会
Publication Date: 1999-12-25
Publication Date (W3CDTF): 1999-12-25
Alternative Title: Neither gynecomastia nor galactorrhea is a common side effect of neuroleptics in male patients
Periodical title: 四国医学雑誌
No. or year of volume/issue: 55 6
Volume: 55
Issue: 6
Pages: 232-233
ISSN (Periodical Title): ISSN : 0037-3699
Text Language Code: jpn
Subject Heading: estradiol
galactorrhea
gonadotropins
gynecomastia
neuroleptics
prolactin
testosterone
Target Audience: 一般
Note (General): Gynecomastia is known to be a side effect of neuroleptics. The authors investigated the prevalence of gynecomastia and galactorrhea in a group of regularly neuroleptic-treated male patients. Methods : Gynecomastia was defined as a palpable, discrete button of firm subareolar tissue measuring at least 2 cm in diameter. The subjects were 100 male patients who were taking neuroleptic-treatment regularly. Each patient gave informed consent for the research involved in this study. Results : (1) Palpable gynecomastia was present in 2% of the patient group, but not at all in the normal group. (2) Galactorrhea was not present in either patient or normal group. (3) The mean level of the serum prolactin in the group of patients without gynecomastia was significantly higher than that in the normal group, but there was no significant difference in blood luteinizing hormone, follicle-stimulating hormone, testosterone (T), estradiol (E 2) or T/E2 ratio between the groups. (4) The mean level of the T/E2 ratio in the patients with gynecomastia was tended to be higher than that in the group of patients without gynecomastia. Conclusions : Overall, theseresults seem to indicate that (i) gynecomastia is not popular in the Japanese population, and (ii) in male patients, neither palpable gynecomastia nor galactorrhea is a common side effect of neuroleptics. To clarify the relation between gynecomastia and neuroleptic treatment, large prospective studies are required.
Format (IMT): application/pdf
Source: https://repo.lib.tokushima-u.ac.jp/files/public/11/112165/20180831115240884452/sam_55_6_232.PDF
https://repo.lib.tokushima-u.ac.jp/files/public/11/112165/20180831115240884452/sam_55_6_232.PDF
Access Restrictions: 限定公開
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ