Impact of the use of Kampo medicine in patients with esophageal cancer during chemotherapy : a clinical trial for oral hygiene and oral condition

• Material Type: 博士論文
• Title: Impact of the use of Kampo medicine in patients with esophageal cancer during chemotherapy : a clinical trial for oral hygiene and oral condition
• Author/Editor: Moriyama, Satomi; Hinode, Daisuke; Yoshioka, Masami; Sogawa, Yuka; Nishino, Takeshi; Tangoku, Akira; Grenier, Daniel
• Author Heading: Moriyama, Satomi; Hinode, Daisuke; Yoshioka, Masami; Sogawa, Yuka; Nishino, Takeshi; Tangoku, Akira; Grenier, Daniel
• Publication, Distribution, etc.: Faculty of Medicine Tokushima University
• Publication Date: 2018-08
• Publication Date (W3CDTF): 2018-08
• Alternative Title: 食道がん化学療法患者における漢方薬使用の効果 : 口腔衛生および口腔内状態に関する臨床研究; Kampo medicine for esophageal cancer treatment
• Periodical title: The Journal of Medical Investigation
• No. or year of volume/issue: 65 3-4
• Volume: 65
• Issue: 3-4
• Pages: 184-190
• ISSN (Periodical Title): ISSN : 1349-6867; ISSN : 1343-1420
• Degree grantor/type: 徳島大学
• Date Granted: 2020-03-23
• Dissertation Number: 甲第3374号
• Degree Type: 博士（口腔保健学）
• Text Language Code: eng
• Subject Heading: Kampo medicine; esophageal cancer; periodontopathogenic bacteria; gingival inflammation
• Target Audience: 一般
• Note (General): Objective : The aim of this study was to investigate the impact of the use of two Kampo medicines on oral mucositis, tongue coating bacteria, and gingiva condition in patients with esophageal cancer undergoing chemotherapy. Methods : Twenty-three esophageal cancer patients who receive chemotherapy at Tokushima University Hospital, were included. The participants, who received professional oral healthcare, were randomly divided into three groups : 7 subjects received Daiokanzoto sherbets, 7 subjects received Hangeshashinto sherbets, and 9 subjects received nothing (control). The numbers of total bacteria and specific periodontopathogenic bacteria in tongue coating were determined in addition to clinical parameters. Results : No difference on the onset of oral mucositis was found among the three groups. However, tongue coating index, gingival index (GI), plaque index, the number of total bacteria, Fusobacterium nucleatum and Campylobacter rectus were decreased during chemotherapy. More specifically, GI as well as the number of F. nucleatum and C. rectus were decreased significantly in the Daiokanzoto group when compared to the controlgroup (p<0.05). No such differences were observed for the group receiving Hangeshashinto. Conclusion : This clinical trial showed that Daiokanzoto might be effective in attenuating gingival inflammation and reducing the levels of periodontopathogenic bacteria in patients with esophageal cancer.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.2152/jmi.65.184
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

Table of Contents

http://repo.lib.tokushima-u.ac.jp/files/public/11/112235/20200414112851441617/k3374_abstract.pdf fulltext

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