Urinary type IV collagen excretion is involved in the decline in estimated glomerular filtration rate in the Japanese general population without diabetes : A 5-year observational study

• Material Type: 博士論文
• Title: Urinary type IV collagen excretion is involved in the decline in estimated glomerular filtration rate in the Japanese general population without diabetes : A 5-year observational study
• Author/Editor: Kishi, Fumi; Nagai, Kojiro; Takamatsu, Norimichi; Tominaga, Tatsuya; Tamaki, Masanori; Shibata, Eriko; Murakami, Taichi; Kishi, Seiji; Abe, Hideharu; Koezuka, Yasuhiko; Minagawa, Naoto; Ichien, Go; Doi, Toshio
• Author Heading: Kishi, Fumi; Nagai, Kojiro; Takamatsu, Norimichi; Tominaga, Tatsuya; Tamaki, Masanori; Shibata, Eriko; Murakami, Taichi; Kishi, Seiji; Abe, Hideharu; Koezuka, Yasuhiko; Minagawa, Naoto; Ichien, Go; Doi, Toshio
• Publication, Distribution, etc.: PLOS
• Publication Date: 2018-04-06
• Publication Date (W3CDTF): 2018-04-06
• Alternative Title: 尿中IV型コラーゲン排泄は非糖尿病日本人一般住民の推定糸球体濾過量の低下に関与する : 5年間の観察研究; Urinary type IV collagen excretion in the Japanese general population without diabetes
• Periodical title: PLOS ONE
• No. or year of volume/issue: 13 4
• Volume: 13
• Issue: 4
• Pages: e0195523-
• ISSN (Periodical Title): ISSN : 1932-6203
• Degree grantor/type: 徳島大学
• Date Granted: 2018-05-24
• Dissertation Number: 甲第3197号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Urinary type IV collagen; eGFR; without diabetes; Japanese general population; Chronic Kidney Desease
• Target Audience: 一般
• Note (General): Urinary type IV collagen (U-Col4) and albumin excretion is evaluated to monitor the development of diabetic kidney disease. However, U-Col4 excretion in the general population without diabetes has not yet been fully elucidated. In this study, 1067 participants without diabetes and with urinary albumin-creatinine ratio <300 mg/gCr (normo- or microalbuminuria) who underwent an annual health examination in 2004 were enrolled and observed for 5 years. They were divided according to the amount of U-Col4 or urinary albumin excreted. The decline in estimated glomerular filtration rate (eGFR) was calculated. In participants with eGFR ≥80 mL/min, abnormal U-Col4 excretion was indicated as a significant independent risk factor for 10% eGFR change per year, which is one of the prognostic factors for the development of end-stage kidney disease. Moreover, in contrast to urinary albumin excretion, U-Col4 excretion was not related to age or kidney function, suggesting that some individuals with abnormal U-Col4 excretion can have an independent hidden risk for the development of kidney dysfunction. In conclusion, it is important to measure U-Col4 excretion in the general population without diabetes to determine changes in renal features in every individual and help detect future complications such as diabetic kidney disease. If U-Col4 excretion is abnormal, kidney manifestation should be carefully followed up, even if the kidney function and urinalysis findings are normal.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Rights (production): Copyright: © 2018 Kishi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.( https://creativecommons.org/licenses/by/4.0/ )
• Related Material (DOI): 10.1371/journal.pone.0195523
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

Table of Contents

http://repo.lib.tokushima-u.ac.jp/files/public/11/112361/2019082816003060188/k3197_abstract_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/112361/20190828160030373612/k3197_fulltext.pdf fulltext