Hydrocortisone administration was associated with improved survival in Japanese patients with cardiac arrest

• Material Type: 博士論文
• Title: Hydrocortisone administration was associated with improved survival in Japanese patients with cardiac arrest
• Author/Editor: Niimura, Takahiro; Zamami, Yoshito; Koyama, Toshihiro; Izawa-Ishizawa, Yuki; Miyake, Masashi; Koga, Tadashi; Harada, Keisaku; Ohshima, Ayako; Imai, Toru; Kondo, Yutaka; Imanishi, Masaki; Takechi, Kenshi; Fukushima, Keijo; Horinouchi, Yuya; Ikeda, Yasumasa; Fujino, Hiromichi; Tsuchiya, Koichiro; Tamaki, Toshiaki; Hinotsu, Shiro; Kano, Mitsunobu R.; Ishizawa, Keisuke
• Author Heading: Niimura, Takahiro; Zamami, Yoshito; Koyama, Toshihiro; Izawa-Ishizawa, Yuki; Miyake, Masashi; Koga, Tadashi; Harada, Keisaku; Ohshima, Ayako; Imai, Toru; Kondo, Yutaka; Imanishi, Masaki; Takechi, Kenshi; Fukushima, Keijo; Horinouchi, Yuya; Ikeda, Yasumasa; Fujino, Hiromichi; Tsuchiya, Koichiro; Tamaki, Toshiaki; Hinotsu, Shiro; Kano, Mitsunobu R.; Ishizawa, Keisuke
• Publication, Distribution, etc.: Springer Nature
• Publication Date: 2017-12-20
• Publication Date (W3CDTF): 2017-12-20
• Alternative Title: ヒドロコルチゾン投与は日本人心肺停止患者の生存率改善に関連する
• Periodical title: Scientific Reports
• No. or year of volume/issue: 7
• Volume: 7
• Pages: 17919-
• ISSN (Periodical Title): ISSN : 2045-2322
• Degree grantor/type: 徳島大学
• Date Granted: 2021-03-23
• Dissertation Number: 甲第3502号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Hydrocortisone; Cardiac arrest; Database
• Target Audience: 一般
• Note (General): There are few reports on hydrocortisone administration after cardiac arrest, and those that have been published included few subjects. This study aimed to evaluate the effect of hydrocortisone administration on the outcomes of patients who experienced cardiac arrest. We investigated the survival discharge rates and the length of hospital stay from cardiac arrest to discharge, stratified by use of hydrocortisone, using a Japanese health-insurance claims dataset that covers approximately 2% of the Japanese population. The study included the data of 2233 subjects who experienced either in-hospital or out-of-hospital cardiac arrest between January 2005 and May 2014. These patients were divided into two groups, based on the administration of hydrocortisone. We adjusted the baseline characteristics, medical treatment, and drug administration data of the two groups using propensity scores obtained via the inverse probability of treatment weighted method. The hydrocortisone group had a significantly higher survival discharge rate (13/61 [21.1%] vs. 240/2172 [11.0%], adjusted odds ratio: 4.2, 95% CI: 1.60–10.98, p = 0.004). In addition, the administration of hydrocortisone was independent predictor of survival to discharge (hazard ratio: 4.6, p < 0.001). The results demonstrate a correlation between hydrocortisone administration and the high rates of survival to discharge.
• Format (IMT): application/pdf; application/msword
• Access Restrictions: インターネット公開
• Rights (production): © The Author(s) 2017 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
• Related Material (DOI): 10.1038/s41598-017-17686-3
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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http://repo.lib.tokushima-u.ac.jp/files/public/11/112397/202104141616547835/k3502_abstract_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/112397/20210414161654517405/k3502_fulltext.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/112397/20210414161655550890/srep_7_17919_s1.doc fulltext