Effects of anesthetic agents on in vivo axonal HCN current in normal mice

• Material Type: 博士論文
• Title: Effects of anesthetic agents on in vivo axonal HCN current in normal mice
• Author/Editor: Osaki, Yusuke; Nodera, Hiroyuki; Banzrai, Chimeglkham; Endo, Sachiko; Takayasu, Hirokazu; Mori, Atsuko; Shimatani, Yoshimitsu; Kaji, Ryuji
• Author Heading: Osaki, Yusuke; Nodera, Hiroyuki; Banzrai, Chimeglkham; Endo, Sachiko; Takayasu, Hirokazu; Mori, Atsuko; Shimatani, Yoshimitsu; Kaji, Ryuji
• Publication, Distribution, etc.: Elsevier
• Publication Date: 2015-01-19
• Publication Date (W3CDTF): 2015-01-19
• Alternative Title: 正常マウスにおける軸索HCN電流へ麻酔薬が及ぼす影響
• Periodical title: Clinical Neurophysiology
• No. or year of volume/issue: 126 10
• Volume: 126
• Issue: 10
• Pages: 2033-2039
• ISSN (Periodical Title): ISSN : 1388-2457
• Degree grantor/type: 徳島大学
• Date Granted: 2018-09-13
• Dissertation Number: 甲第3207号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Axonal excitability; Anesthetics; HCN channel
• Target Audience: 一般
• Note (General): Objective: The objective was to study the in vivo effects of anesthetic agents on peripheral nerve excitability. Methods: Normal male mice were anesthetized by either isoflurane inhalation or a combination of medetomidine, midazolam, and butorphanol intraperitoneal injection (‘‘triple agents’’). Immediately after induction, the tail sensory nerve action potential was recorded and its excitability was monitored. Results: Under both anesthetic protocols, there was an interval excitability change by long hyperpolarizing currents. There was greater threshold reduction approximately 30 min post induction, in comparison to immediately post induction. Other excitability parameters were stable over time. Modeling suggested interval suppression of internodal H conductance or leak current. Conclusions: Anesthetic agents affected responses to long hyperpolarizing currents. Significance: Axonal excitability during intraoperative monitoring may be affected by anesthetic agents. Interpretation of interval excitability changes under anesthesia requires caution, especially with long hyperpolarizing currents.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1016/j.clinph.2014.12.025
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

Table of Contents

http://repo.lib.tokushima-u.ac.jp/files/public/11/112753/20181205175822231206/k3207_abstract_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/112753/20181205175822549767/k3207_fulltext.pdf fulltext