Development-related changes in the expression of the ovarian Kiss1 and Kiss1r genes and their sensitivity to human chorionic gonadotropin in prepubertal female rats

• Material Type: 博士論文
• Title: Development-related changes in the expression of the ovarian Kiss1 and Kiss1r genes and their sensitivity to human chorionic gonadotropin in prepubertal female rats
• Author/Editor: Yamasaki, Mikio; Kuwahara, Akira; Iwasa, Takeshi; Yamamoto, Yuri; Taniguchi, Yuka; Yano, Yuya; Matsui, Sumika; Matsuzaki, Toshiya; Irahara, Minoru
• Author Heading: Yamasaki, Mikio; Kuwahara, Akira; Iwasa, Takeshi; Yamamoto, Yuri; Taniguchi, Yuka; Yano, Yuya; Matsui, Sumika; Matsuzaki, Toshiya; Irahara, Minoru
• Publication, Distribution, etc.: Society for Reproduction and Development
• Publication Date: 2017-05-27
• Publication Date (W3CDTF): 2017-05-27
• Alternative Title: 幼若雌ラットにおける発育に伴う卵巣Kiss1,Kiss1r遺伝子発現の変動およびHCGに対する感受性; OVARIAN Kiss1 mRNA IN THE PREPUBERTAL PERIOD
• Periodical title: Journal of Reproduction and Development
• No. or year of volume/issue: 63 4
• Volume: 63
• Issue: 4
• Pages: 409-414
• ISSN (Periodical Title): ISSN : 1348-4400; ISSN : 0916-8818
• Degree grantor/type: 徳島大学
• Date Granted: 2017-09-28
• Dissertation Number: 甲第3105号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Development; kisspeptin; Kiss1; Kiss1r; Ovary
• Target Audience: 一般
• Note (General): Kisspeptin, which is encoded by the Kiss1 gene, and its receptor, the G protein-coupled receptor 54 (Kiss1r), play important roles in the regulation of reproductive functions in mammals. Several studies have shown that the Kiss1 and Kiss1r genes are expressed in the rat, primate, and human ovaries, and that the ovarian kisspeptin system plays a pivotal role in ovulation at the proestrous stage in adulthood. The purpose of this study was to evaluate development-related changes in the expression of ovarian Kiss1 and Kiss1r genes and in kisspeptin levels, and to identify the regulatory factors for these genes during the prepubertal period. The serum kisspeptin level was also measured to examine whether ovarian kisspeptin affects serum kisspeptin levels. Variations in the ovarian Kiss1 and Kiss1r mRNA levels were observed during the prepubertal period in female rats, with levels peaking around postnatal days 20 and 15, respectively. Nevertheless, the ovarian kisspeptin content per total protein level was stably maintained. Serum kisspeptin levels at postnatal days 30 and 35 were higher than those at earlier postnatal days. The pattern of the ovarian Kiss1 mRNA levels was similar to that of the serum luteinizing hormone (LH) levels, and the ovarian Kiss1 mRNA level increased after injection with human chorionic gonadotropin (HCG) on postnatal day 20, but not on postnatal days 10 and 30. These data indicate that ovarian Kiss1 and Kiss1r mRNA levels are increased on postnatal days 20 and 15, respectively, and that changes in the serum LH level and the ovarian sensitivity to LH may be involved in the alteration of ovarian Kiss1 mRNA levels.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Rights (production): ©2017 Society for Reproduction and Development This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
• Related Material (DOI): 10.1262/jrd.2016-179
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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