Endogenous progesterone levels could predict reproductive outcome in frozen embryo replacement cycles supplemented with synthetic progestogens : A retrospective cohort study

• Material Type: 博士論文
• Title: Endogenous progesterone levels could predict reproductive outcome in frozen embryo replacement cycles supplemented with synthetic progestogens : A retrospective cohort study
• Author/Editor: Kawachiya, Satoshi; Bodri, Daniel; Hirosawa, Toshikazu; Serna, Jazmina Yao; Kuwahara, Akira; Irahara, Minoru
• Author Heading: Kawachiya, Satoshi; Bodri, Daniel; Hirosawa, Toshikazu; Serna, Jazmina Yao; Kuwahara, Akira; Irahara, Minoru
• Publication, Distribution, etc.: Wiley|Japan Society for Reproductive Medicine
• Publication Date: 2018-11-01
• Publication Date (W3CDTF): 2018-11-01
• Alternative Title: 内因性プロゲステロン分泌は、合成プロゲステロン製剤を用いたホルモン補充凍結胚移植周期において妊娠予後予測因子になり得る
• Periodical title: Reproductive Medicine and Biology
• No. or year of volume/issue: 18 1
• Volume: 18
• Issue: 1
• Pages: 91-96
• ISSN (Periodical Title): ISSN : 1447-0578
• Degree grantor/type: 徳島大学
• Date Granted: 2019-02-06
• Dissertation Number: 甲第3252号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: progesterone; blastocyst transfer; fertilization in vitro; single embryo transfer; luteoplacental shift; dydrogesterone; placental progesterone
• Target Audience: 一般
• Note (General): Purpose: A retrospective, cohort study was conducted between 2009 and 2017 in a private infertility center to determine the predictive value of endogenous estrogen (E2) and progesterone (P4) levels in hormone‐replacement frozen embryo replacement (FER) treatment cycles. Methods: A total of 120 consecutive, infertile patients who became pregnant after FER cycles were analyzed (age: 37.4 ± 4.4 years). Electively vitrified blastocysts were created during natural cycle IVF or mild ovarian stimulation treatments and subsequently transferred through delayed vitrified‐thawed blastocyst transfer cycles supplemented with estrogens and a combination of synthetic progestogens. Serum E2 and progesterone P4 levels were intensively monitored every five days (from the day after embryo transfer until 9w1d of pregnancy) and compared among patients with a subsequent live birth (n = 76) or first‐trimester pregnancy loss (n = 44). Results: Endogenous placental activity started as early as 5‐6th pregnancy week differing significantly according to pregnancy outcome. For P4, the exponential rise from 6w2d onwards allowed distinguishing between failing and successful conceptions. For P4, lower quartiles of the live birth group did not intersect with upper quartiles of the miscarriage group. Conclusions: Innovative FER protocols incorporating synthetic progestogens allow the correct measurement of endogenous placental activity and could help to monitor early first‐trimester ART pregnancies.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Rights (production): This is an open access article under the terms of the Creative Commons Attribution-NonCommercial‐NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. © 2018 The Authors. Reproductive Medicine and Biology published by John Wiley & Sons Australia, Ltd on behalf of Japan Society for Reproductive Medicine.
• Related Material (DOI): 10.1002/rmb2.12254
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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