Lipopolysaccharide promotes early endometrial-peritoneal interactions in a mouse model of endometriosis

• Material Type: 博士論文
• Title: Lipopolysaccharide promotes early endometrial-peritoneal interactions in a mouse model of endometriosis
• Author/Editor: Keyama, Kaoru; Kato, Takeshi; Kadota, Yuri; Erdenebayar, Otgontsetseg; Kasai, Kana; Kawakita, Takako; Tani, Anna; Matsui, Sumika; Iwasa, Takeshi; Yoshida, Kanako; Maegawa, Masahiko; Kuwahara, Akira; Matsuzaki, Toshiya; Irahara, Minoru
• Author Heading: Keyama, Kaoru; Kato, Takeshi; Kadota, Yuri; Erdenebayar, Otgontsetseg; Kasai, Kana; Kawakita, Takako; Tani, Anna; Matsui, Sumika; Iwasa, Takeshi; Yoshida, Kanako; Maegawa, Masahiko; Kuwahara, Akira; Matsuzaki, Toshiya; Irahara, Minoru
• Publication, Distribution, etc.: Tokushima University Faculty of Medicine
• Publication Date: 2019-02
• Publication Date (W3CDTF): 2019-02
• Alternative Title: 子宮内膜症モデルマウスにおいてLPSは腹膜子宮内膜症初期病巣形成を促進する; LPS proliferate the endometriosis
• Periodical title: The Journal of Medical Investigation
• No. or year of volume/issue: 66 1-2
• Volume: 66
• Issue: 1-2
• Pages: 70-74
• ISSN (Periodical Title): ISSN : 1349-6867; ISSN : 1343-1420
• Degree grantor/type: 徳島大学
• Date Granted: 2018-12-27
• Dissertation Number: 甲第3248号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: LPS; endometriosis; inflammation; Murine model; cytokine; mice model
• Target Audience: 一般
• Note (General): Purpose : The aims of this study were to clarify the effects of lipopolysaccharide (LPS) on the early development of endometriosis and on the production of cytokines and chemokines in the murine peritoneal cavity. Methods : Endometriotic lesions were induced in C57BL/6J adult female mice by intraperitoneal injection of endometrial fragments plus blood or endometrial fragments plus blood with LPS. On day 7, endometriotic lesions were assessed by gross and microscopic evaluations. Time-dependent changes in the secretion of TNF-α, IL-6, and CXCL2/MIP-2 in peritoneal lavage fluid after the intraperitoneal injection of LPS (50 µg/body) were measured by their respective enzyme-linked immunosorbent assays. Results : The areas of endometriotic lesions in the LPS group (10.8±8.6 mm2) were significantly larger than those in the control group (3.1±3.7 mm2). The levels of TNF-α and IL-6 peaked within 2 hours and the level of MIP-2 reached a maximum on day 1 after the injection of LPS. Conclusions : LPS promotes development of the early stages of murine endometriotic lesions.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.2152/jmi.66.70
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

Table of Contents

http://repo.lib.tokushima-u.ac.jp/files/public/11/113324/20190729154044866564/k3248_abstract_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/113324/20190730181516822691/k3248_fulltext.pdf fulltext