Long-term polarization of alveolar macrophages to a profibrotic phenotype after inhalation exposure to multi-wall carbon nanotubes

• Material Type: 博士論文
• Title: Long-term polarization of alveolar macrophages to a profibrotic phenotype after inhalation exposure to multi-wall carbon nanotubes
• Author/Editor: Otsuka, Kunihiro; Yamada, Koichi; Taquahashi, Yuhji; Arakaki, Rieko; Ushio, Aya; Saito, Masako; Yamada, Akiko; Tsunematsu, Takaaki; Kudo, Yasusei; Kanno, Jun; Ishimaru, Naozumi
• Author Heading: Otsuka, Kunihiro; Yamada, Koichi; Taquahashi, Yuhji; Arakaki, Rieko; Ushio, Aya; Saito, Masako; Yamada, Akiko; Tsunematsu, Takaaki; Kudo, Yasusei; Kanno, Jun; Ishimaru, Naozumi
• Publication, Distribution, etc.: PLOS
• Publication Date: 2018-10-29
• Publication Date (W3CDTF): 2018-10-29
• Alternative Title: 多層カーボンナノチューブの吸入曝露による線維化誘導型肺胞マクロファージへの長期変化; Effect of CNT exposure on alveolar macrophages
• Periodical title: PLOS ONE
• No. or year of volume/issue: 13 10
• Volume: 13
• Issue: 10
• Pages: e0205702-
• ISSN (Periodical Title): ISSN : 1932-6203
• Degree grantor/type: 徳島大学
• Date Granted: 2019-03-22
• Dissertation Number: 甲第3281号
• Degree Type: 博士（歯学）
• Text Language Code: eng
• Subject Heading: Carbon nanotube; Taquann methods; alveolar macrophage; fibrosis; lung
• Target Audience: 一般
• Note (General): Background Nanomaterials are widely used in various fields. Although the toxicity of carbon nanotubes (CNTs) in pulmonary tissues has been demonstrated, the toxicological effect of CNTs on the immune system in the lung remains unclear. Methods and finding In this study, exposure to Taquann-treated multi-walled CNTs (T-CNTs) was performed using aerosols generated in an inhalation chamber. At 12 months after T-CNT exposure, alveolar inflammation with macrophage accumulation and hypertrophy of the alveolar walls were observed. In addition, fibrotic lesions were enhanced by T-CNT exposure. The macrophages in the bronchoalveolar lavage fluid of T-CNT-exposed mice were not largely shifted to any particular population, and were a mixed phenotype with M1 and M2 polarization. Moreover, the alveolar macrophages of T-CNT-exposed mice produced matrix metalloprotinase-12. Conclusions These results suggest that T-CNT exposure promoted chronic inflammation and fibrotic lesion formation in profibrotic macrophages for prolonged periods.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Rights (production): © 2018 Otsuka et al. This is an open access article distributed under the terms of the Creative Commons Attribution License( https://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
• Related Material (DOI): 10.1371/journal.pone.0205702
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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http://repo.lib.tokushima-u.ac.jp/files/public/11/113371/20190610094209823325/k3281_abstract.pdf fulltext

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