Appropriate Surgical Treatment of Symptomatic Primary Varicose Veins Decreases Systemic Inflammatory Biomarkers

• Material Type: 博士論文
• Title: Appropriate Surgical Treatment of Symptomatic Primary Varicose Veins Decreases Systemic Inflammatory Biomarkers
• Author/Editor: Arase, Hiroki; Sugasawa, Noriko; Kawatani, Youhei; Sugano, Mikio; Kurobe, Hirotsugu; Fujimoto, Eiki; Kitaichi, Takashi; Kitagawa, Tetsuya
• Author Heading: Arase, Hiroki; Sugasawa, Noriko; Kawatani, Youhei; Sugano, Mikio; Kurobe, Hirotsugu; Fujimoto, Eiki; Kitaichi, Takashi; Kitagawa, Tetsuya
• Publication, Distribution, etc.: The Editorial Committee of Annals of Vascular Diseases
• Publication Date: 2019-08-05
• Publication Date (W3CDTF): 2019-08-05
• Alternative Title: 症候性1次性下肢静脈瘤の適切な外科手術は全身性の炎症性物質を軽減する; Systemic Activation of Biomarkers by Varix
• Periodical title: Annals of Vascular Diseases
• No. or year of volume/issue: 12 3
• Volume: 12
• Issue: 3
• Pages: 367-371
• ISSN (Periodical Title): ISSN : 1881-641X; ISSN : 1881-6428
• Degree grantor/type: 徳島大学
• Date Granted: 2019-09-26
• Dissertation Number: 甲第3335号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: varicose vein; inflammatory biomarkers; IL-6; MCP-1; endovenous laser ablation
• Target Audience: 一般
• Note (General): Objective: To evaluate the relationship between systemic inflammatory biomarkers and efficacy of surgical treatment of primary varicose veins of the lower extremities. Methods: Total 12 patients who underwent endovenous laser ablation or stripping of varicose veins and six healthy subjects were enrolled. Structural and molecular changes of varices were assessed by immunohistochemical staining with anti-monocyte chemotactic protein-1 (MCP-1). MCP-1 and interleukin-6 (IL-6) levels in systemic antecubital blood were measured before and at 12 weeks after treatment. Results: Immunohistochemical staining revealed prominent manifestation of MCP-1-positive endothelial cells in the walls of varices. Preoperative serum MCP-1 and IL-6 levels in the patients were significantly higher than those in the control (166±12 pg/mL vs 99±10 pg/mL, p=0.003; 5.1±0.95 pg/mL vs 0.0±0.0 pg/mL, p=0.001, respectively). The values were significantly correlated with the severity of chronic venous insufficiency (CVI). Postoperative serum MCP-1 level significantly decreased compared with the preoperative level (152±10 pg/mL vs 166±12 pg/mL, p=0.048). The values after endovenous laser ablation did not significantly decrease compared with those after stripping. Conclusion: Varicose veins with CVI increase inflammatory biomarker levels in the local tissue and systemic blood. Appropriate treatment of symptomatic varicose veins decreases inflammatory biomarker levels.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Rights (production): ©2019 The Editorial Committee of Annals of Vascular Diseases. This article is distributed under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided the credit of the original work, a link to the license, and indication of any change are properly given, and the original work is not used for commercial purposes. Remixed or transformed contributions must be distributed under the same license as the original.
• Related Material (DOI): 10.3400/avd.oa.19-00011
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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