Association of accumulated advanced glycation end‐products with a high prevalence of sarcopenia and dynapenia in patients with type 2 diabetes

• Material Type: 博士論文
• Title: Association of accumulated advanced glycation end‐products with a high prevalence of sarcopenia and dynapenia in patients with type 2 diabetes
• Author/Editor: Mori, Hiroyasu; Kuroda, Akio; Ishizu, Masashi; Ohishi, Mami; Takashi, Yuichi; Otsuka, Yinhua; Taniguchi, Satoshi; Tamaki, Motoyuki; Kurahashi, Kiyoe; Yoshida, Sumiko; Endo, Itsuro; Aihara, Ken-ichi; Funaki, Makoto; Akehi, Yuko; Matsuhisa, Munehide
• Author Heading: Mori, Hiroyasu; Kuroda, Akio; Ishizu, Masashi; Ohishi, Mami; Takashi, Yuichi; Otsuka, Yinhua; Taniguchi, Satoshi; Tamaki, Motoyuki; Kurahashi, Kiyoe; Yoshida, Sumiko; Endo, Itsuro; Aihara, Ken-ichi; Funaki, Makoto; Akehi, Yuko; Matsuhisa, Munehide
• Publication, Distribution, etc.: Asian Association for the Study of Diabetes|John Wiley & Sons Australia
• Publication Date: 2019-01-24
• Publication Date (W3CDTF): 2019-01-24
• Alternative Title: 2型糖尿病患者における終末糖化産物の蓄積とサルコペニアおよびダイナペニアとの関連; Dynapenia and AGEs in type 2 diabetes
• Periodical title: Journal of Diabetes Investigation
• No. or year of volume/issue: 10 5
• Volume: 10
• Issue: 5
• Pages: 1332-1340
• ISSN (Periodical Title): ISSN : 2040-1124
• Degree grantor/type: 徳島大学
• Date Granted: 2020-09-10
• Dissertation Number: 乙第2114号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: 糖尿病; 終末糖化産物; サルコペニア; ダイナペニア; Advanced glycation end-products; Dynapenia; Sarcopenia
• Target Audience: 一般
• Note (General): Aims/Introduction: Advanced glycation end-products (AGEs), which are a major cause of diabetic vascular complications, accumulate in various tissues under chronic hyperglycemic conditions, as well as with aging in patients with diabetes. The loss of muscle mass and strength, so-called sarcopenia and dynapenia, has recently been recognized as a diabetic complication. However, the influence of accumulated AGEs on muscle mass and strength remains unclear. The present study aimed to evaluate the association of sarcopenia and dynapenia with accumulated AGEs in patients with type 2 diabetes. Materials and Methods: We recruited 166 patients with type 2 diabetes aged ≥30 years (mean age 63.2 ± 12.3 years; body mass index 26.3 ± 4.9 kg/m2; glycated hemoglobin 7.1 ± 1.1%). Skin autofluorescence as a marker of AGEs, limb skeletal muscle mass index, grip strength, knee extension strength and gait speed were assessed. Results: Sarcopenia and dynapenia were observed in 7.2 and 13.9% of participants, respectively. Skin autofluorescence was significantly higher in patients with sarcopenia and dynapenia. Skin autofluorescence was the independent determinant for skeletal muscle mass index, grip strength, knee extension strength, sarcopenia and dynapenia. Conclusions: Accumulated AGEs could contribute to reduced muscle mass and strength, leading to sarcopenia and dynapenia in patients with type 2 diabetes.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Rights (production): © 2019 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License(https://creativecommons.org/licenses/by-nc/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
• Related Material (DOI): 10.1111/jdi.13014
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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