Trajectories of class-switching-related egg and cow's milk allergen-specific immunoglobulin isotype formation and its modification by eczema with low- and high-affinity immunoglobulin E during early infancy

• Material Type: 博士論文
• Title: Trajectories of class-switching-related egg and cow's milk allergen-specific immunoglobulin isotype formation and its modification by eczema with low- and high-affinity immunoglobulin E during early infancy
• Author/Editor: Irahara, Makoto; Shinahara, Wakako; Sugimoto, Mayumi; Ogawa, Yukiko; Shitsukawa, Keiji; Kubota, Kenji; Yang, Limin; Ohya, Yukihiro; Saito, Hirohisa; Kagami, Shoji; Arisawa, Kokichi; Kido, Hiroshi
• Author Heading: Irahara, Makoto; Shinahara, Wakako; Sugimoto, Mayumi; Ogawa, Yukiko; Shitsukawa, Keiji; Kubota, Kenji; Yang, Limin; Ohya, Yukihiro; Saito, Hirohisa; Kagami, Shoji; Arisawa, Kokichi; Kido, Hiroshi
• Publication, Distribution, etc.: Wiley
• Publication Date: 2019-03-11
• Publication Date (W3CDTF): 2019-03-11
• Alternative Title: 乳児期早期における鶏卵、牛乳アレルゲン特異的免疫グロブリンのクラススイッチを伴うアイソタイプ形成経過と、湿疹による低親和性、高親和性の抗原特異的IgE抗体の形成
• Periodical title: Immunity, Inflammation and Disease
• No. or year of volume/issue: 7 2
• Volume: 7
• Issue: 2
• Pages: 74-85
• ISSN (Periodical Title): ISSN : 2050-4527
• Degree grantor/type: 徳島大学
• Date Granted: 2020-01-23
• Dissertation Number: 甲第3345号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: allergen microarray; eczema; food allergy; high‐affinity immunoglobulin E; immunoglobulin isotype formation; low‐affinity immunoglobulin E
• Target Audience: 一般
• Note (General): Introduction: Allergen‐specific immunoglobulin isotype formation associated with immunoglobulin class‐switching during the lactation period is the immunological background for food allergy in infants. We analyzed the serial changes in the production of feeding type‐related egg‐ and milk‐specific immunoglobulin isotypes from birth to 6 months of age with or without eczema in 84 infants. Methods: Allergen‐specific immunoglobulin G1 (IgG1), IgG2, IgG3, IgG4, IgA, and IgE levels of hen’s egg and bovine milk were measured in cord blood and blood samples from infants at 2, 4, and 6 months of age by the densely carboxylated protein microarray. Results: Formula and mixed feeding were associated with a rapid increase in cow’s milk allergen‐specific immunoglobulins and feeding type‐related significant differences in casein‐specific immunoglobulin levels were detected. Breast and mixed feeding were associated with slow but significant increase in ovalbumin‐specific IgG1 and IgE levels, but not other immunoglobulins. We found two different immunoglobulin isotype formation at 6 months of age with low‐ or high‐affinity IgE against ovalbumin. One isotype formation pattern had relatively high ovalbumin‐specific IgG1 levels, detectable IgG2, and low‐affinity IgE, while the other had low ovalbumin‐specific IgG1 levels, undetectable IgG2, and high levels of high‐affinity IgE. The incidence of eczema was significantly higher in the latter pattern (84.6%), compared with the remaining infants (42.2%). Conclusions: Feeding practice‐related allergen sensitization and immunoglobulin isotype formation were identified during the lactation period. The development of eczema during the lactation period could potentially modify the immunoglobulin isotype formation with high levels of high‐affinity IgE.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Rights (production): This is an open access article under the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/4.0/ ), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
• Related Material (DOI): 10.1002/iid3.245
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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