Sleep profile during fasting in PPAR-alpha knockout mice

• Material Type: 博士論文
• Title: Sleep profile during fasting in PPAR-alpha knockout mice
• Author/Editor: Kondo, Yoshitsugu; Chikahisa, Sachiko; Shiuchi, Tetsuya; Shimizu, Noriyuki; Tanioka, Daisuke; Uguisu, Haruo; Séi, Hiroyoshi
• Author Heading: Kondo, Yoshitsugu; Chikahisa, Sachiko; Shiuchi, Tetsuya; Shimizu, Noriyuki; Tanioka, Daisuke; Uguisu, Haruo; Séi, Hiroyoshi
• Publication, Distribution, etc.: Elsevier
• Publication Date: 2019-11-27
• Publication Date (W3CDTF): 2019-11-27
• Alternative Title: ペルオキシソーム増殖因子活性化受容体アルファノックアウトマウスの絶食時における睡眠変化
• Periodical title: Physiology & Behavior
• No. or year of volume/issue: 214
• Volume: 214
• Pages: 112760-
• ISSN (Periodical Title): ISSN : 0031-9384
• Degree grantor/type: 徳島大学
• Date Granted: 2020-03-18
• Dissertation Number: 甲第3365号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: PPARα; Sleep; Food deprivation; Ketone bodies
• Target Audience: 一般
• Note (General): Peroxisome proliferator-activated receptor alpha (PPARα) is a transcription factor that belongs to the nuclear receptor family and plays an important role in regulating gene expression associated with lipid metabolism. PPARα promotes hepatic fatty acid oxidation and ketogenesis in response to fasting. Because energy metabolism is known to affect sleep regulation, manipulations that change PPARα are likely to affect sleep and other physiological phenotypes. In this study, we examined the role of PPARα in sleep/wake regulation using PPARα knockout (KO) mice. Sleep, body temperature (BT), locomotor activity, arterial pressure (AP) and heart rate (HR) were recorded in KO mice and wild-type (WT) controls under ad libitum-fed conditions and 24-hour food deprivation (FD). KO and WT mice were identical in basal sleep amount, BT, mean AP and HR, although KO mice showed enhanced sleepiness (enhanced EEG slow-wave activity). In response to FD, KO mice showed a large drop in wakefulness and locomotor activity at the end of the dark phase, whereas WT mice did not. Similarly, AP and HR, which were suppressed by FD, decreased more in KO than in WT mice. Compared to WT mice, KO mice showed a reduced concentration of plasma ketone bodies and decreased mRNA expression of the ketogenic enzyme gene Hmgcs2 in the liver and brain under FD conditions. These results suggest that PPARα and/or lipid metabolism is involved in the maintenance of wakefulness and locomotor activity during fasting in mice.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1016/j.physbeh.2019.112760
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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