Plasma substance P concentrations in patients undergoing general anesthesia : an objective marker associated with postoperative nausea and vomiting

• Material Type: 博士論文
• Title: Plasma substance P concentrations in patients undergoing general anesthesia : an objective marker associated with postoperative nausea and vomiting
• Author/Editor: 池﨑, 尚子; Kakuta, Nami; Horikawa, Yousuke T.; Tsutsumi, Rie; Oyama, Takuro; Tanaka, Katsuya; Tsutsumi, Yasuo M.
• Author Heading: 池﨑, 尚子; Kakuta, Nami; Horikawa, Yousuke T.; Tsutsumi, Rie; Oyama, Takuro; Tanaka, Katsuya; Tsutsumi, Yasuo M.
• Publication, Distribution, etc.: Japanese Society of Anesthesiologists|Springer Nature
• Publication Date: 2016-06-02
• Publication Date (W3CDTF): 2016-06-02
• Alternative Title: 全身麻酔下の患者の血漿サブスタンスP濃度 : 術後嘔気・嘔吐の有用な指標となる
• Periodical title: JA Clinical Reports
• No. or year of volume/issue: 2
• Volume: 2
• Pages: 9-
• ISSN (Periodical Title): ISSN : 2363-9024
• Degree grantor/type: 徳島大学
• Date Granted: 2020-04-23
• Dissertation Number: 甲第3425号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: General anesthesia; Plasma substance P; PONV; Substance P
• Target Audience: 一般
• Note (General): Background: This study investigated plasma concentrations of substance P (SP) in patients undergoing general anesthesia (GA) and postoperative nausea and vomiting (PONV). This prospective, observational, cohort study included 23 patients who underwent scheduled surgery under general anesthesia. Blood was collected from the radial artery at predetermined time points (15–30 mins prior anesthesia, 15–30 mins after surgery/GA, and 24 h after surgery). PONV, SP concentrations, risk factors, and analgesics used were measured. Findings: Nine of 23 patients experienced PONV. In patients without PONV, SP concentrations significantly decreased (P < 0.0001) at the end of surgery/GA, compared to baseline, and recovered at 24 h after surgery/GA (452.9 ± 146.2 vs. 666.9 ± 176.5 vs. 580.7 ± 168.6 pg/mL, respectively), whereas SP levels were unchanged during surgery/GA and increased at 24 hours after surgery (P = 0.020) in patients with PONV (726.1 ± 167.8 vs. 655.8 ± 168.0 vs. 779.7 ± 220.7 pg/mL, respectively). Conclusions: These finding suggest that SP levels may be utilized as an objective marker for PONV.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Rights (production): © 2016 Kadota et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
• Related Material (DOI): 10.1186/s40981-016-0034-9
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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