Influence of albumin leakage on glycated albumin in patients with type 2 diabetes undergoing hemodialysis

• Material Type: 博士論文
• Title: Influence of albumin leakage on glycated albumin in patients with type 2 diabetes undergoing hemodialysis
• Author/Editor: Ueda, Sayo; Nagai, Kojiro; Yokota, Narushi; Hirose, Daisuke; Mori, Hiroaki; Noma, Yoshihiko; Doi, Toshio; Minakuchi, Jun
• Author Heading: Ueda, Sayo; Nagai, Kojiro; Yokota, Narushi; Hirose, Daisuke; Mori, Hiroaki; Noma, Yoshihiko; Doi, Toshio; Minakuchi, Jun
• Publication, Distribution, etc.: Springer nature|The Japanese Society for Artificial Organs
• Publication Date: 2019-02-25
• Publication Date (W3CDTF): 2019-02-25
• Alternative Title: 2型糖尿病血液透析患者のグリコアルブミンに対するアルブミン漏出の影響; Albumin leakage and glycoalbumin in patients with diabetes undergoing hemodialysis
• Periodical title: Journal of Artificial Organs
• No. or year of volume/issue: 22 3
• Volume: 22
• Issue: 3
• Pages: 264-267
• ISSN (Periodical Title): ISSN : 1434-7229; ISSN : 1619-0904
• Degree grantor/type: 徳島大学
• Date Granted: 2020-03-23
• Dissertation Number: 甲第3362号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Albumin; Hemodialysis; Glycated albumin; HbA1c
• Target Audience: 一般
• Note (General): Glycated albumin (GA) is recommended as a better glycemic indicator than HbA1c in patients undergoing hemodialysis, because red blood cell lifespan is generally faster than that in normal subjects and easily altered by blood loss and erythropoiesis-stimulating agent administration. However, GA can be also affected by protein loss in urine and hemodialysis fluid. Therefore, in this study, we investigated the effect of albumin leakage induced by hemodialysis on GA in a crossover manner. Nine patients undergoing hemodialysis with large or small amounts of albumin leakage were observed for nine months. Valuables indicating glycemic control, albumin and hemoglobin metabolism and nutritional status were evaluated. As a result, it was shown that albumin leakage could affect GA, but the effect was practically small considering the prescription of diabetic drugs. The correlation between HbA1c and blood glucose levels was similar with that between GA and blood glucose levels in our study. In conclusion, GA was a reliable indicator, even with the change of hemodialysis modality. The influence of clinically acceptable albumin leakage induced by hemodialysis on GA was negligible practically. We should recognize that the preferable glycemic indicator in patients undergoing hemodialysis depends on the hemoglobin and albumin metabolism of each patient.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1007/s10047-019-01097-4
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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