Serum biotin level during pregnancy is associated with fetal growth and preterm delivery

• Material Type: 博士論文
• Title: Serum biotin level during pregnancy is associated with fetal growth and preterm delivery
• Author/Editor: Ichihara, Yuko; Suga, Kenichi; Fukui, Maika; Yonetani, Naoto; Shono, Miki; Nakagawa, Ryuji; Kagami, Shoji
• Author Heading: Ichihara, Yuko; Suga, Kenichi; Fukui, Maika; Yonetani, Naoto; Shono, Miki; Nakagawa, Ryuji; Kagami, Shoji
• Publication, Distribution, etc.: Tokushima University Faculty of Medicine
• Publication Date: 2020-02
• Publication Date (W3CDTF): 2020-02
• Alternative Title: 妊娠中の血清ビオチン濃度は胎児の成長と早産に関連する; Serum biotin level during pregnancy
• Periodical title: The Journal of Medical Investigation
• No. or year of volume/issue: 67 1-2
• Volume: 67
• Issue: 1-2
• Pages: 170-173
• ISSN (Periodical Title): ISSN : 1349-6867; ISSN : 1343-1420
• Degree grantor/type: 徳島大学
• Date Granted: 2020-03-18
• Dissertation Number: 甲第3368号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: biotin; pregnancy; preterm birth; fetal growth restriction; small for gestational age
• Target Audience: 一般
• Note (General): Background : Biotin is a water-soluble vitamin that plays various biological roles through histone modification, such as immune functions and fetal growth. Mammalian maternal biotin deficiency during gestation induces fetal growth restriction. Preterm infants are known to be marginal biotin deficiency. However, studies on the biotin status of pregnant women under various conditions are lacking. Method : This was a retrospective case control study to analyze serum biotin concentration during pregnancy and cord blood in normal pregnancy, preterm delivery and small-for-gestational-age (SGA). Results : Twenty pregnant women with normal term delivery, 35 with preterm delivery, 24 with SGA, and 10 non-pregnant adult women were enrolled. Serum biotin concentrations of pregnant women remained low from first to third trimester. The levels of serum biotin in cord blood showed a significant positive correlation with gestational age, and that of pregnant women showed a weak positive correlation with gestational age. The maternal serum biotin levels during second and third trimester of SGA group were significantly lower than those of normal term delivery. Conclusion : This study suggests that maternal biotin deficiency during pregnancy might be the risk of preterm labor or fetal growth restriction. Further studies are required to clarify the roles of biotin in perinatal medicine.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.2152/jmi.67.170
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

Table of Contents

http://repo.lib.tokushima-u.ac.jp/files/public/11/114736/20200514150218230285/k3368_abstract_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/114736/20200610104450268218/k3368_fulltext.pdf fulltext