Reproducibility and Variability of Quantitative Cerebral Blood Flow Measured by Multi-delay 3D Arterial Spin Labeling According to Sex and Menstrual Cycle

• Material Type: 博士論文
• Title: Reproducibility and Variability of Quantitative Cerebral Blood Flow Measured by Multi-delay 3D Arterial Spin Labeling According to Sex and Menstrual Cycle
• Author/Editor: Otomo, Maki; Harada, Masafumi; Abe, Takashi; Matsumoto, Yuki; Abe, Yumi; Kanazawa, Yuki; Miyoshi, Mitsuharu; Kabasawa, Hiroyuki; Takahashi, Yoshitake
• Author Heading: Otomo, Maki; Harada, Masafumi; Abe, Takashi; Matsumoto, Yuki; Abe, Yumi; Kanazawa, Yuki; Miyoshi, Mitsuharu; Kabasawa, Hiroyuki; Takahashi, Yoshitake
• Publication, Distribution, etc.: Tokushima University Faculty of Medicine
• Publication Date: 2020-08
• Publication Date (W3CDTF): 2020-08
• Alternative Title: 多重遅延3D動脈スピン標識法で測定した定量的脳血流の再現性および性別および月経周期の違いによる変動性について; Reproducibility of CBF using pCASL
• Periodical title: The Journal of Medical Investigation
• No. or year of volume/issue: 67 3-4
• Volume: 67
• Issue: 3-4
• Pages: 321-327
• ISSN (Periodical Title): ISSN : 1349-6867; ISSN : 1343-1420
• Degree grantor/type: 徳島大学
• Date Granted: 2020-09-10
• Dissertation Number: 甲第3433号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: neuroimaging; arterial spin labeling (ASL); cerebral blood flow (CBF); 3DSRT; gender difference
• Target Audience: 一般
• Note (General): Purpose : To determine the reproducibility of corrected quantitative cerebral blood flow (qCBF) through measurement of transit flow time using multi-delay three-dimensional pseudo-continuous arterial spin labeling (pCASL) in healthy men and women and to evaluate the differences in qCBF between not only men and women, but also the follicular and luteal phases of the women’s menstrual cycle. Methods : The participants were 16 healthy volunteers (8 men and 8 women ; mean age, 25.3 years). Two MRI were conducted for all participants ; female participants were conducted in the follicular and luteal phases. The reproducibility of qCBF values was evaluated by the intraclass correlation coefficient (ICC) and differences between the two groups were estimated by voxel-based morphometry (VBM) analysis. Results : The qCBF values were lower in men than in women, and those in females were significantly different between the follicular and luteal phases (P < 0.05). In VBM analysis, the qCBF values of the lower frontal lobes were significantly higher in women than in men (P < 0.05). The qCBF values of the frontal pole were significantly higher in the follicular phase than in the luteal phase (P < 0.01). Conclusion : Multi-delay pCASL can reveal physiological and sex differences in cerebral perfusion.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.2152/jmi.67.321
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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http://repo.lib.tokushima-u.ac.jp/files/public/11/115293/20200924170315820280/k3433_abstract_review.pdf fulltext

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