Long-term outcomes of the Japanese hemodialysis patients with prostate cancer detected by prostate-specific antigen screening

• Material Type: 博士論文
• Title: Long-term outcomes of the Japanese hemodialysis patients with prostate cancer detected by prostate-specific antigen screening
• Author/Editor: Yokota, Narushi; Takahashi, Masayuki; Nishitani, Masaaki; Minakuchi, Jun; Kanayama, Hiro-Omi
• Author Heading: Yokota, Narushi; Takahashi, Masayuki; Nishitani, Masaaki; Minakuchi, Jun; Kanayama, Hiro-Omi
• Publication, Distribution, etc.: Tokushima University Faculty of Medicine
• Publication Date: 2021-02
• Publication Date (W3CDTF): 2021-02
• Alternative Title: 前立腺特異抗原スクリーニングにより発見された前立腺癌を有する日本人血液透析患者の長期的な転帰; PSA screening in hemodialysis patients
• Periodical title: The Journal of Medical Investigation
• No. or year of volume/issue: 68 1-2
• Volume: 68
• Issue: 1-2
• Pages: 42-47
• ISSN (Periodical Title): ISSN : 1349-6867; ISSN : 1343-1420
• Degree grantor/type: 徳島大学
• Date Granted: 2021-01-28
• Dissertation Number: 甲第3470号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: hemodialysis; prostate cancer; PSA
• Target Audience: 一般
• Note (General): We investigated the long-term outcomes of the Japanese hemodialysis patients with prostate cancer detected by prostate-specific antigen (PSA) screening. Clinical data of 646 male hemodialysis patients aged 55 years or older who started yearly PSA testing in the period from January 1, 2004 to December 31, 2012 and were followed until December 31, 2017 were analyzed retrospectively. The median follow-up period was 10.4 years. Nineteen (2.9%) patients were diagnosed with prostate cancer, of whom one patient died of the disease. Androgen-deprivation therapy (ADT) was selected for primary prostate cancer treatment in 17 (89.5%) of these 19 patients. Of six prostate cancer patients who underwent primary ADT (PADT) and died of other causes, three died of infectious disease, each one died of cardiovascular disease, liver cancer, and chronic renal failure. No significant difference was observed in regard to overall survival between the prostate cancer patients with PADT and non-prostate cancer patients. Prognosis of hemodialysis patients who were diagnosed with prostate cancer during yearly PSA screening examination and mainly treated with ADT was favorable without increasing cardiovascular events. This result indicates that PSA screening may be useful for detection and management of prostate cancer even in hemodialysis patients.
• Format (IMT): application/pdf
• Source: comment：fulltext; http://repo.lib.tokushima-u.ac.jp/files/public/11/115627/20210202153254780651/k3470_abstract_review.pdf; http://repo.lib.tokushima-u.ac.jp/files/public/11/115627/20210519100941884712/k3470_fulltext.pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.2152/jmi.68.42
• Periodical Title (NCID): AA11166929; https://ci.nii.ac.jp/ncid/AA11166929
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ