Effects of L-/N-Type Calcium Channel Blockers on Angiotensin II–Renin Feedback in Hypertensive Patients

• Material Type: 博士論文
• Title: Effects of L-/N-Type Calcium Channel Blockers on Angiotensin II–Renin Feedback in Hypertensive Patients
• Author/Editor: Kawabata, Yutaka; Soeki, Takeshi; Ito, Hiroyuki; Matsuura, Tomomi; Kusunose, Kenya; Ise, Takayuki; Yamaguchi, Koji; Tobiume, Takeshi; Yagi, Shusuke; Fukuda, Daiju; Yamada, Hirotsugu; Wakatsuki, Tetsuzo; Kitani, Mitsuhiro; Kawano, Kazuhiro; Taketani, Yoshio; Sata, Masataka
• Author Heading: Kawabata, Yutaka; Soeki, Takeshi; Ito, Hiroyuki; Matsuura, Tomomi; Kusunose, Kenya; Ise, Takayuki; Yamaguchi, Koji; Tobiume, Takeshi; Yagi, Shusuke; Fukuda, Daiju; Yamada, Hirotsugu; Wakatsuki, Tetsuzo; Kitani, Mitsuhiro; Kawano, Kazuhiro; Taketani, Yoshio; Sata, Masataka
• Publication, Distribution, etc.: Hindawi
• Publication Date: 2020-12-22
• Publication Date (W3CDTF): 2020-12-22
• Alternative Title: 高血圧患者におけるアンジオテンシン II-レニンフィードバック機構に対するL/N型カルシウムチャネル拮抗薬の影響
• Periodical title: International Journal of Hypertension
• No. or year of volume/issue: 2020
• Volume: 2020
• Pages: 6653851-
• ISSN (Periodical Title): ISSN : 2090-0384; ISSN : 2090-0392
• Degree grantor/type: 徳島大学
• Date Granted: 2021-02-25
• Dissertation Number: 甲第3478号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: L-/N-type calcium channel blocker; renoprotective effect; suppressing renin-angiotensin system; the ratio of Angiotensin-(1–7)/Angiotensin II
• Target Audience: 一般
• Note (General): Objectives. Cilnidipine, an L-/N-type calcium channel blocker (CCB), has unique organ-protective properties due to suppression of hyperactivity in the sympathetic nervous system and renin-angiotensin system (RAS). In this study, we hypothesized that cilnidipine might exert a renoprotective effect by suppressing the RAS. Methods. A total of 25 hypertensive patients receiving a RAS inhibitor were randomly assigned to a cilnidipine (n = 12) or amlodipine (n = 13) group. The effects of cilnidipine on proteinuria and angiotensin II–renin feedback were assessed. Results. After 6 months of treatment, both systolic and diastolic blood pressures were significantly reduced to a similar extent in both groups. The urine albumin-to-creatinine ratio was significantly lower in the cilnidipine group (p < 0.05) than in the amlodipine group. Amlodipine increased plasma angiotensin I and angiotensin II levels (p < 0.05), whereas cilnidipine did not. Interestingly, the cilnidipine group had a higher ratio of angiotensin-(1–7) (Ang-(1–7)) to angiotensin II in plasma than the amlodipine group (p < 0.05). Conclusions. The L-/N-type CCB cilnidipine, but not amlodipine, decreased urinary albumin excretion in hypertensive patients. Cilnidipine also increased the ratio of Ang-(1–7) to angiotensin II in plasma, which might be one factor underlying its beneficial effects.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Rights (production): Copyright © 2020 Yutaka Kawabata et al. This is an open access article distributed under the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
• Related Material (DOI): 10.1155/2020/6653851
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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