Development of TX-816 and its derivatives as 5-Aminolevurinic acid-based photodynamic therapy sensitizer

• Material Type: 博士論文
• Title: Development of TX-816 and its derivatives as 5-Aminolevurinic acid-based photodynamic therapy sensitizer
• Author/Editor: 篠原, 侑成
• Author Heading: 篠原, 侑成
• Publication Date: 2021-03-23
• Publication Date (W3CDTF): 2021-03-23
• Alternative Title: 5-アミノレブリン酸を用いた光線力学療法増感剤としてのTX-816及びその誘導体の開発
• Degree grantor/type: 徳島大学
• Date Granted: 2021-03-23
• Dissertation Number: 甲第3514号
• Degree Type: 博士（工学）
• Text Language Code: eng
• Subject Heading: 5-Aminolevulinic acid; Protoporphyrin IX; Photodynamic therapy; Schiff base
• Target Audience: 一般
• Note (General): 5-Aminolevulinic acid (ALA), a precursor of protoporphyrin IX (PpIX), is now widely used for photodynamic therapy (ALA-PDT) of various cancers. Recently, I found that treatment of cancer cells with the Schiff base derivative TX-816 along with ALA could significantly increase the efficacy of ALA-PDT. This enhancing effect of TX-816 on ALA-PDT is attributed to 3,5-dichlorosalicylaldehyde (DCSA), a molecule produced by the degradation of TX-816. Similar to TX-816, DCSA significantly enhances the effect of ALA-PDT. Furthermore, DCSA could restore the sensitivity of cancer cells that acquired resistance to ALA-PDT. These results indicate that DCSA, as well as TX-816, is a potent lead compound for the development of an ALA-PDT sensitizer.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

Table of Contents

http://repo.lib.tokushima-u.ac.jp/files/public/11/115991/20210521162350124435/k3514_abstract.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/115991/20210521162350485328/k3514_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/115991/20210521162350817223/k3514_fulltext.pdf fulltext