Urinary adiponectin excretion is an early predictive marker of the decline of the renal function in patients with diabetes mellitus

• Material Type: 博士論文
• Title: Urinary adiponectin excretion is an early predictive marker of the decline of the renal function in patients with diabetes mellitus
• Author/Editor: Ishizu, Masashi; Mori, Hiroyasu; Ohishi, Mami; Kuroda, Akio; Akehi, Yuko; Yoshida, Sumiko; Aihara, Ken-ichi; Aiba, Motohiro; Kawano, Tomoharu; Hashida, Seiichi; Matsuhisa, Munehide
• Author Heading: Ishizu, Masashi; Mori, Hiroyasu; Ohishi, Mami; Kuroda, Akio; Akehi, Yuko; Yoshida, Sumiko; Aihara, Ken-ichi; Aiba, Motohiro; Kawano, Tomoharu; Hashida, Seiichi; Matsuhisa, Munehide
• Publication, Distribution, etc.: Elsevier
• Publication Date: 2021-01-07
• Publication Date (W3CDTF): 2021-01-07
• Alternative Title: 尿中アディポネクチン排泄は糖尿病患者における腎機能低下の早期予測指標である。; Urinary adiponectin in DKD
• Periodical title: Journal of Diabetes and its Complications
• No. or year of volume/issue: 35 4
• Volume: 35
• Issue: 4
• Pages: 107848-
• ISSN (Periodical Title): ISSN : 1056-8727
• Degree grantor/type: 徳島大学
• Date Granted: 2021-03-23
• Dissertation Number: 甲第3503号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: diabetes kidney disease; urinary adiponectin; estimated glomerular filtration rate
• Target Audience: 一般
• Note (General): Aims: Since diabetes-associated kidney complication changes from diabetic nephropathy to diabetic kidney disease (DKD), more suitable biomarkers than urinary albumin are required. It has been hypothesized that urinary adiponectin (u-ADPN) is associated with the progression of DKD. We therefore evaluated the effectiveness of u-ADPN in predicting the decline of the renal function in patients with diabetes prior to end-stage renal disease. Methods: An ultrasensitive immune complex transfer enzyme immunoassay (ICT-EIA) was used to measure total and high molecular weight (HMW) adiponectin separately. We evaluated the relationships between the creatinine-adjusted urinary total-ADPN and HMW-ADPN, albumin (UACR) and liver-type fatty acid binding protein (L-FABP) at baseline and the 2-year change of the estimated glomerular filtration rate (ΔeGFR). Results: This 2-year prospective observational study included 201 patients with diabetes. These patients were divided into three groups according to their ΔeGFR: ≤-10 ml/min/1.73m2, >-10 and ≤0 ml/min/1.73m2, and >0 ml/min/1.73m2. Jonckheere-Terpstra test showed that lower ΔeGFR was associated with higher u-HMW-ADPN (p = 0.045). In logistic regression analysis, u-HMW-ADPN was associated with ΔeGFR after adjusted age, sex, and basal eGFR. Conclusion: Urinary HMW-ADPN could predict a declining renal function in patients with diabetes.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Rights (production): © 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
• Related Material (DOI): 10.1016/j.jdiacomp.2021.107848
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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