Effects of peripheral oxytocin administration on body weight, food intake, adipocytes, and biochemical parameters in peri- and postmenopausal female rats

• Material Type: 博士論文
• Title: Effects of peripheral oxytocin administration on body weight, food intake, adipocytes, and biochemical parameters in peri- and postmenopausal female rats
• Author/Editor: Erdenebayar, Otgontsetseg; Kato, Takeshi; Kawakita, Takako; Kasai, Kana; Kadota, Yuri; Yoshida, Kanako; Iwasa, Takeshi; Irahara, Minoru
• Author Heading: Erdenebayar, Otgontsetseg; Kato, Takeshi; Kawakita, Takako; Kasai, Kana; Kadota, Yuri; Yoshida, Kanako; Iwasa, Takeshi; Irahara, Minoru
• Publication, Distribution, etc.: The Japan Endocrine Society
• Publication Date: 2021-01-28
• Publication Date (W3CDTF): 2021-01-28
• Alternative Title: 周閉経期および閉経期ラットにおける体重、摂食量、脂肪細胞および生化学検査項目に対するオキシトシンの末梢投与の影響; Effects of oxytocin in postmenopausal rats
• Periodical title: Endocrine Journal
• No. or year of volume/issue: 68 1
• Volume: 68
• Issue: 1
• Pages: 7-16
• ISSN (Periodical Title): ISSN : 0918-8959; ISSN : 1348-4540
• Degree grantor/type: 徳島大学
• Date Granted: 2021-03-23
• Dissertation Number: 甲第3499号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Oxytocin; peri- and postmenopause; metabolic function; feeding function; Menopause; Body weight; Food intake; Adipocyte
• Target Audience: 一般
• Note (General): Recent studies have revealed that the administration of oxytocin has beneficial effects on the regulation of body weight, food intake, and metabolic functions, especially in obese individuals. Obesity is common in women after the menopause and drives many components of metabolic syndrome. Weight gain in menopausal women has been frequently reported. Although obesity and associated metabolic disorders are frequently observed in peri- and postmenopausal women, there are few medical interventions for these conditions. In this study, we evaluated the effects of chronic oxytocin administration on appetite, body weight, and fat mass in peri- and postmenopausal female rats. Sixteen naturally premenopausal or menopausal rats were intraperitoneally injected with oxytocin (1,000 μg/day) for 12 days. The daily changes in their body weight and food intake were measured at the same time as the oxytocin and vehicle injections. Intraperitoneally administering oxytocin for 12 days significantly reduced food intake, body weight, and visceral adipocyte size. In addition, oxytocin administration caused reductions in serum triglyceride and low-density lipoprotein-cholesterol levels, while it did not disturb hepatic or renal functions or locomotor activity. This is the first study to show the effects of oxytocin on the metabolic and feeding functions of peri- and postmenopausal female rats. Oxytocin might be a useful treatment for metabolic disorders caused by the menopause or aging.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Rights (production): © The Japan Endocrine Society
• Related Material (DOI): 10.1507/endocrj.EJ19-0586
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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