Intracranial mast cells contribute to the control of social behavior in male mice

• Material Type: 博士論文
• Title: Intracranial mast cells contribute to the control of social behavior in male mice
• Author/Editor: Tanioka, Daisuke; Chikahisa, Sachiko; Shimizu, Noriyuki; Shiuchi, Tetsuya; Sakai, Noriaki; Nishino, Seiji; Séi, Hiroyoshi
• Author Heading: Tanioka, Daisuke; Chikahisa, Sachiko; Shimizu, Noriyuki; Shiuchi, Tetsuya; Sakai, Noriaki; Nishino, Seiji; Séi, Hiroyoshi
• Publication, Distribution, etc.: Elsevier
• Publication Date: 2021-01-28
• Publication Date (W3CDTF): 2021-01-28
• Alternative Title: 雄性マウス頭蓋内肥満細胞が担う社会性行動の調節
• Periodical title: Behavioural Brain Research
• No. or year of volume/issue: 403
• Volume: 403
• Pages: 113143-
• ISSN (Periodical Title): ISSN : 0166-4328
• Degree grantor/type: 徳島大学
• Date Granted: 2021-03-23
• Dissertation Number: 甲第3500号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Mast cell; Social behavior; Intracranium; Serotonin; Compound 48/80
• Target Audience: 一般
• Note (General): Mast cells (MCs) exist intracranially and have been reported to affect higher brain functions in rodents. However, the role of MCs in the regulation of emotionality and social behavior is unclear. In the present study, using male mice, we examined the relationship between MCs and social behavior and investigated the underlying mechanisms. Wild-type male mice intraventricularly injected with a degranulator of MCs exhibited a marked increase in a three-chamber sociability test. In addition, removal of MCs in Mast cell-specific Toxin Receptor-mediated Conditional cell Knock out (Mas-TRECK) male mice showed reduced social preference levels in a three-chamber sociability test without other behavioral changes, such as anxiety-like and depression-like behavior. Mas-TRECK male mice also had reduced serotonin content and serotonin receptor expression and increased oxytocin receptor expression in the brain. These results suggested that MCs may contribute to the regulation of social behavior in male mice. This effect may be partially mediated by serotonin derived from MCs in the brain.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1016/j.bbr.2021.113143
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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http://repo.lib.tokushima-u.ac.jp/files/public/11/116053/20210615095230596307/k3500_abstract_review.pdf fulltext

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