Association between Socioeconomic Status and Digestive Tract Cancers : A Case-Control Study

• Material Type: 博士論文
• Title: Association between Socioeconomic Status and Digestive Tract Cancers : A Case-Control Study
• Author/Editor: Kawakatsu, Yukino; Koyanagi, Yuriko N.; Oze, Isao; Kasugai, Yumiko; Morioka, Hisayoshi; Yamaguchi, Rui; Ito, Hidemi; Matsuo, Keitaro
• Author Heading: Kawakatsu, Yukino; Koyanagi, Yuriko N.; Oze, Isao; Kasugai, Yumiko; Morioka, Hisayoshi; Yamaguchi, Rui; Ito, Hidemi; Matsuo, Keitaro
• Publication, Distribution, etc.: MDPI
• Publication Date: 2020-11-04
• Publication Date (W3CDTF): 2020-11-04
• Alternative Title: 社会経済的地位と消化器がんの関係について : 症例対照研究
• Periodical title: Cancers
• No. or year of volume/issue: 12 11
• Volume: 12
• Issue: 11
• Pages: 3258-
• ISSN (Periodical Title): ISSN : 2072-6694
• Degree grantor/type: 徳島大学
• Date Granted: 2021-03-23
• Dissertation Number: 甲第3507号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Socioeconomic status; digestive tract cancer; cancer risk; case-control study; areal deprivation index
• Target Audience: 一般
• Note (General): Although socioeconomic status (SES) has been associated with cancer risk, little research on this association has been done in Japan. To evaluate the association between SES and digestive tract cancer risk, we conducted a case-control study for head and neck, esophageal, stomach, and colorectal cancers in 3188 cases and the same number of age- and sex-matched controls within the framework of the Hospital-based Epidemiological Research Program at Aichi Cancer Center III (HERPACC III). We employed the education level and areal deprivation index (ADI) as SES indicators. The association was evaluated with odds ratios (ORs) and 95% confidence intervals (CIs) by conditional logistic models adjusted for potential confounders. Even after allowance for known cancer risk factors, the education level showed linear inverse associations with head and neck, stomach, and colorectal cancers. Compared to those educated to junior high school, those with higher education showed statistically significantly lower risks of cancer (0.43 (95% CI: 0.27–0.68) for head and neck, 0.52(0.38–0.69) for stomach, and 0.52(0.38–0.71) for colorectum). Consistent with these results for the educational level, the ADI in quintiles showed positive associations with head and neck, esophageal, and stomach cancers (p-trend: p = 0.035 for head and neck, p = 0.02 for esophagus, and p = 0.013 for stomach). Interestingly, the positive association between ADI and stomach cancer risk disappeared in the additional adjustment for Helicobacter pylori infection and/or atrophic gastritis status. In conclusion, a lower SES was associated with an increased risk of digestive cancers in Japan and should be considered in cancer prevention policies for the target population.; An association between socioeconomic status (SES) and cancer risk has been reported, but little is known in Asia. We revealed an association between SES, including education level and areal deprivation index (ADI), and digestive tract cancers in Japan. Lower SES was associated with an increased risk of digestive cancers. For stomach cancer, the positive association with ADI disappeared following an additional adjustment of Helicobacter pylori infection and/or atrophic gastritis status. Cancer prevention policy should consider both individual and regional perspectives by the integration of SES in the target population.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Rights (production): © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
• Related Material (DOI): 10.3390/cancers12113258
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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