Pain sensitivity increases with sleep disturbance under predictable chronic mild stress in mice

• Material Type: 博士論文
• Title: Pain sensitivity increases with sleep disturbance under predictable chronic mild stress in mice
• Author/Editor: Dalanon, Junhel Casinillo; Chikahisa, Sachiko; Shiuchi, Tetsuya; Shimizu, Noriyuki; Chavan, Parimal; Suzuki, Yoshitaka; Okura, Kazuo; Séi, Hiroyoshi; Matsuka, Yoshizo
• Author Heading: Dalanon, Junhel Casinillo; Chikahisa, Sachiko; Shiuchi, Tetsuya; Shimizu, Noriyuki; Chavan, Parimal; Suzuki, Yoshitaka; Okura, Kazuo; Séi, Hiroyoshi; Matsuka, Yoshizo
• Publication, Distribution, etc.: Springer Nature
• Publication Date: 2021-07-09
• Publication Date (W3CDTF): 2021-07-09
• Alternative Title: 軽度な慢性ストレスはマウスの睡眠を障害し疼痛感受性を増大させる
• Periodical title: Scientific Reports
• No. or year of volume/issue: 11
• Volume: 11
• Pages: 14231-
• ISSN (Periodical Title): ISSN : 2045-2322
• Degree grantor/type: 徳島大学
• Date Granted: 2021-09-09
• Dissertation Number: 甲第3542号
• Degree Type: 博士（歯学）
• Text Language Code: eng
• Subject Heading: Hyperalgesia; Predictable chronic mild stress; Sleep; Slow-wave activity; Interleukin-6; Tumor necrosis factor-alpha
• Target Audience: 一般
• Note (General): Even though it has been well documented that stress can lead to the development of sleep disorders and the intensification of pain, their relationships have not been fully understood. The present study was aimed at investigating the effects of predictable chronic mild stress (PCMS) on sleep–wake states and pain threshold, using the PCMS rearing conditions of mesh wire (MW) and water (W) for 21 days. Exposure to PCMS decreased the amount of non-rapid eye movement (NREM) sleep during the dark phase. Moreover, the chronicity of PCMS decreased slow-wave activity (SWA) during NREM sleep in the MW and W groups in both the light and dark phases. Mechanical and aversively hot thermal hyperalgesia were more intensified in the PCMS groups than the control. Higher plasma corticosterone levels were seen in mice subjected to PCMS, whereas TNF-α expression was found higher in the hypothalamus in the W and the trigeminal ganglion in the MW group. The W group had higher expression levels of IL-6 in the thalamus as well. The PCMS paradigm decreased SWA and may have intensified mechanical and thermal hyperalgesia. The current study also suggests that rearing under PCMS may cause impaired sleep quality and heightened pain sensation to painful mechanical and aversively hot thermal stimuli.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Rights (production): This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
• Related Material (DOI): 10.1038/s41598-021-93560-7
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

Table of Contents

http://repo.lib.tokushima-u.ac.jp/files/public/11/116125/20211006151524167094/k3542_abstract.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/116125/20211006151524730082/k3542_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/116125/20211006151525374159/k3542_fulltext.pdf fulltext