Acute Hospital Mortality of Venous Thromboembolism in Patients With Cancer From Registry Data

• Material Type: 博士論文
• Title: Acute Hospital Mortality of Venous Thromboembolism in Patients With Cancer From Registry Data
• Author/Editor: Okushi, Yuichiro; Kusunose, Kenya; Okayama, Yoshihiro; Zheng, Robert; Nakai, Michikazu; Sumita, Yoko; Ise, Takayuki; Tobiume, Takeshi; Yamaguchi, Koji; Yagi, Shusuke; Fukuda, Daiju; Yamada, Hirotsugu; Soeki, Takeshi; Wakatsuki, Tetsuzo; Sata, Masataka
• Author Heading: Okushi, Yuichiro; Kusunose, Kenya; Okayama, Yoshihiro; Zheng, Robert; Nakai, Michikazu; Sumita, Yoko; Ise, Takayuki; Tobiume, Takeshi; Yamaguchi, Koji; Yagi, Shusuke; Fukuda, Daiju; Yamada, Hirotsugu; Soeki, Takeshi; Wakatsuki, Tetsuzo; Sata, Masataka
• Publication, Distribution, etc.: The American Heart Association
• Publication Date: 2021-05-22
• Publication Date (W3CDTF): 2021-05-22
• Alternative Title: レジストリデータによるがん患者の静脈血栓塞栓症の急性期死亡率; Thromboembolism and Cancer
• Periodical title: Journal of the American Heart Association
• No. or year of volume/issue: 10 11
• Volume: 10
• Issue: 11
• Pages: e019373-
• ISSN (Periodical Title): ISSN : 2047-9980
• Degree grantor/type: 徳島大学
• Date Granted: 2021-07-29
• Dissertation Number: 甲第3531号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: cardio-oncology; mortality; venous thromboembolism; Big data
• Target Audience: 一般
• Note (General): BACKGROUND: The prognosis of patients with cancer-venous thromboembolism (VTE) is not well known because of a lack of registry data. Moreover, there is also no knowledge on how specific types are related to prognosis. We sought to evaluate the clinical characteristics and outcomes of patients with cancer-associated VTE, compared with a matched cohort without cancer using real-world registry data of VTE. METHODS AND RESULTS: This study was based on the Diagnosis Procedure Combination database in the JROAD-DPC (Japanese Registry of All Cardiac and Vascular Diseases and the Diagnosis Procedure Combination). Of 5 106 151 total patients included in JROAD-DPC, we identified 49 580 patients who were first hospitalized with VTE from April 2012 to March 2017. Propensity score was estimated with a logistic regression model, with cancer as the dependent variable and 18 clinically relevant covariates. After propensity matching, there were 25 148 patients with VTE with or without cancer. On propensity score-matched analysis with 25 148 patients with VTE, patients with cancer had higher total in-hospital mortality within 7 days (1.3% versus 1.1%, odds ratio [OR], 1.66; 95% CI, 1.31–2.11; P<0.0001), 14 days (2.5% versus 1.5%, OR, 2.07; 95% CI, 1.72–2.49; P<0.0001), and 30 days (4.8% versus 2.0%, OR, 2.85; 95% CI, 2.45–3.31; P<0.0001). On analysis for each type of cancer, in-hospital mortality in 11 types of cancer was significantly high, especially pancreas (OR, 12.96; 95% CI, 6.41–26.20), biliary tract (OR, 8.67; 95% CI, 3.00–25.03), and liver (OR, 7.31; 95% CI, 3.05–17.50). CONCLUSIONS: Patients with cancer had a higher in-hospital acute mortality for VTE than those without cancer, especially in pancreatic, biliary tract, and liver cancers.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Rights (production): © 2021 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
• Related Material (DOI): 10.1161/JAHA.120.019373
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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