Nobiletin suppresses the development of experimental autoimmune encephalomyelitis mediated by modulation of T helper 17 cell differentiation

• Material Type: 博士論文
• Title: Nobiletin suppresses the development of experimental autoimmune encephalomyelitis mediated by modulation of T helper 17 cell differentiation
• Author/Editor: Nakamoto, Akiko; Hirabayashi, Yuwa; Anzaki, Chieri; Nakamoto, Mariko; Shuto, Emi; Sakai, Tohru
• Author Heading: Nakamoto, Akiko; Hirabayashi, Yuwa; Anzaki, Chieri; Nakamoto, Mariko; Shuto, Emi; Sakai, Tohru
• Publication, Distribution, etc.: Society for Free Radical Research Japan
• Publication Date: 2021-09-01
• Publication Date (W3CDTF): 2021-09-01
• Alternative Title: ノビレチンは17型ヘルパーT細胞の分化調節により、実験的自己免疫性脳脊髄炎の発症を抑制する
• Periodical title: Journal of Clinical Biochemistry and Nutrition
• No. or year of volume/issue: 69 2
• Volume: 69
• Issue: 2
• Pages: 145-150
• ISSN (Periodical Title): ISSN : 0912-0009; ISSN : 1880-5086
• Degree grantor/type: 徳島大学
• Date Granted: 2021-07-29
• Dissertation Number: 乙第2117号
• Degree Type: 博士（栄養学）
• Text Language Code: eng
• Subject Heading: experimental autoimmune encephalomyelitis; nobiletin; polymethoxyflavonoid; Th17 differentiation; IL-17A; polymethoxyflavone
• Target Audience: 一般
• Note (General): Multiple sclerosis is an organ-specific autoimmune disease that targets the myelin antigen in the central nervous system. Nobiletin is a dietary polymethoxylated flavonoid found in citrus fruits. In this study, we investigated how nobiletin affects the disease state and immune responses to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis mice. Nobiletin was administered orally from 14 days before immunization until the end of the experiment, and clinical scores were determined. The production levels of interleukin-17A and interferon-γ were measured in a culture supernatant of splenocytes stimulated with myelin oligodendrocyte glycoprotein. In addition, flow cytometric analysis was performed to examine the effect of nobiletin on T cell differentiation in vitro. Admin­istration of nobiletin significantly decreased the clinical score and interleukin-17A production in splenocytes. Furthermore, in vitro analysis showed that nobiletin significantly suppressed Th17 cell differentiation and interleukin-17A production in a dose-dependent manner. The results suggest that nobiletin attenuates experimental autoimmune encephalomyelitis severity through modulation of Th17 cell differentiation.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Rights (production): This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (https://creativecommons.org/licenses/by-nc-nd/4.0/).
• Related Material (DOI): 10.3164/jcbn.20-178
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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