Clusters consisting only of virus types with two mutations in the helicase found by Autoencoder analysis in Washington State, USA

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Author: Miyake, Junほか

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Publication date: 2021-07-22

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Note (General)：: Using an autoencoder-based analysis to classify genomes of SARS-CoV-2 coronaviruses, we found a cluster consisting only of a specific genotype with tw...

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Material Type: 文書・図像類
Title: Clusters consisting only of virus types with two mutations in the helicase found by Autoencoder analysis in Washington State, USA
Author/Editor: Miyake, Jun
Yoshino, Mitsuaki
Sato, Takaaki
Niioka, Hirohiko
Sakata, Yasushi
Nakazawa, Yoshihisa
Author Heading: Miyake, Jun
Yoshino, Mitsuaki
Sato, Takaaki
Niioka, Hirohiko
Sakata, Yasushi
Nakazawa, Yoshihisa
Publication Date: 2021-07-22
Publication Date (W3CDTF): 2021-07-22
Alternative Title: An autoencoder-classified cluster of SARS-CoV-2 strain with two mutations in helicase
Text Language Code: eng
Subject Heading: COVID-19
SARS-CoV-2 (nCoV-2019)
Genome
Helicase
Mutant
Autoencoder
Washington State
Classification
Cluster
Target Audience: 一般
Note (General): Using an autoencoder-based analysis to classify genomes of SARS-CoV-2 coronaviruses, we found a cluster consisting only of a specific genotype with two mutations in the helicase. This virus genotype, called C-type SARS-CoV-2, was almost exclusively prevalent in the United States from March to July 2020. This type of virus, characterized by a pair of the C17747T (P504L) and A17858G (Y541C) mutations on the nsp13 gene, had never been highly prevalent at any other time or in any other part of the world. In the U.S., Washington State was the center of the epidemic, and the C-type viruses, along with the viruses with wild-type helicase, seemed to have aroused the pandemic. In Washington State, USA, the CoViD-19 epidemic during the first two months of the year, starting at the end of February 2020, was mainly caused by the type-C virus. During this period, the infection spread rapidly; from May onwards, the number of viruses with wild-type helicases became higher than that of type-C viruses, and no type-C viruses have been collected since early July. The involvement of the helicase in this COVID-19 disease was discussed.
Format (IMT): application/pdf
Source: http://repo.lib.tokushima-u.ac.jp/files/public/11/116320/20211104161802469181/medrxiv_20210722.pdf
http://repo.lib.tokushima-u.ac.jp/files/public/11/116320/20211104161802469181/medrxiv_20210722.pdf
Access Restrictions: 限定公開
Rights (production): The copyright holder for this preprint is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Related Material (DOI): 10.1101/2021.07.20.21260850
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ