Cardiac reserve by 6-minute walk stress echocardiography in systemic sclerosis

• Material Type: 博士論文
• Title: Cardiac reserve by 6-minute walk stress echocardiography in systemic sclerosis
• Author/Editor: Arase, Miharu; Kusunose, Kenya; Morita, Sae; Yamaguchi, Natsumi; Hirata, Yukina; Nishio, Susumu; Okushi, Yuichiro; Ise, Takayuki; Tobiume, Takeshi; Yamaguchi, Koji; Fukuda, Daiju; Yagi, Shusuke; Yamada, Hirotsugu; Soeki, Takeshi; Wakatsuki, Tetsuzo; Sata, Masataka
• Author Heading: Arase, Miharu; Kusunose, Kenya; Morita, Sae; Yamaguchi, Natsumi; Hirata, Yukina; Nishio, Susumu; Okushi, Yuichiro; Ise, Takayuki; Tobiume, Takeshi; Yamaguchi, Koji; Fukuda, Daiju; Yagi, Shusuke; Yamada, Hirotsugu; Soeki, Takeshi; Wakatsuki, Tetsuzo; Sata, Masataka
• Publication, Distribution, etc.: BMJ Publishing Group|British Cardiovascular Society
• Publication Date: 2021-02-19
• Publication Date (W3CDTF): 2021-02-19
• Alternative Title: 全身性強皮症における6分間歩行負荷心エコー図検査での左室予備能の評価
• Periodical title: Open Heart
• No. or year of volume/issue: 8 1
• Volume: 8
• Issue: 1
• Pages: e001559-
• ISSN (Periodical Title): ISSN : 2053-3624
• Degree grantor/type: 徳島大学
• Date Granted: 2022-03-23
• Dissertation Number: 甲第3596号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: left ventricular diastolic dysfunction; pulmonary hypertension; exercise echocardiography; systemic sclerosis
• Target Audience: 一般
• Note (General): Objectives There is a high prevalence of left ventricular diastolic dysfunction (LVDD) in systemic sclerosis (SSc) which is associated with high mortality. Thus, early detection of LVDD could be important in management of SSc. We hypothesised that exercise echocardiography in SSc patients with normal resting haemodynamics may expose early phase LVDD, which could affect its prognosis, defined as cardiovascular death and unplanned hospitalisation for heart failure. Methods Between January 2014 and December 2018, we prospectively enrolled 140 patients with SSc who underwent 6-minute walk (6MW) stress echocardiographic studies with normal range of estimated mean pulmonary arterial pressure (mPAP) (<25 mm Hg) and mean pulmonary artery wedge pressure (mPAWP) (<15 mm Hg) at rest. We used ΔmPAP/Δcardiac output (CO) to assess pulmonary vascular reserve and ΔmPAWP/ΔCO to assess LV cardiac reserve between resting and post-6MW. Results During a median period of 3.6 years (IQR 2.0–5.1 years), 25 patients (18%) reached the composite outcome. Both ΔmPAP/ΔCO and ΔmPAWP/ΔCO in patients with events were significantly greater than in those without events (8.9±3.8 mm Hg/L/min vs 3.0±1.7 mm Hg/L/min; p=0.002, and 2.2±0.9 mm Hg/L/min vs 0.9±0.5 mm Hg/L/min; p<0.001, respectively). Patients with both impaired LV cardiac reserve (ΔmPAWP/ΔCO>1.4 mm Hg/L/min) and impaired pulmonary vascular reserve (ΔmPAP/ΔCO>3.0 mm Hg/L/min) had worse outcomes compared with those without these abnormalities (p<0.001). Conclusion The 6MW stress echocardiography revealed impaired LV cardiac reserve in SSc patients with normal resting haemodynamics. Furthermore, LV cardiac reserve independently associates with clinical worsening in SSc, providing incremental prognostic utility, in addition to pulmonary vascular parameters.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Rights (production): This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
• Related Material (DOI): 10.1136/openhrt-2020-001559
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

Table of Contents

http://repo.lib.tokushima-u.ac.jp/files/public/11/116465/20220408110817168982/k3596_abstract_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/116465/20220408110817583334/k3596_fulltext.pdf fulltext