Atherosclerotic Coronary Plaque Is Associated With Adventitial Vasa Vasorum and Local Inflammation in Adjacent Epicardial Adipose Tissue in Fresh Cadavers

• Material Type: 博士論文
• Title: Atherosclerotic Coronary Plaque Is Associated With Adventitial Vasa Vasorum and Local Inflammation in Adjacent Epicardial Adipose Tissue in Fresh Cadavers
• Author/Editor: Ito, Hiroyuki; Wakatsuki, Tetsuzo; Yamaguchi, Koji; Fukuda, Daiju; Kawabata, Yutaka; Matsuura, Tomomi; Kusunose, Kenya; Ise, Takayuki; Tobiume, Takeshi; Yagi, Shusuke; Yamada, Hirotsugu; Soeki, Takeshi; Tsuruo, Yoshihiro; Sata, Masataka
• Author Heading: Ito, Hiroyuki; Wakatsuki, Tetsuzo; Yamaguchi, Koji; Fukuda, Daiju; Kawabata, Yutaka; Matsuura, Tomomi; Kusunose, Kenya; Ise, Takayuki; Tobiume, Takeshi; Yagi, Shusuke; Yamada, Hirotsugu; Soeki, Takeshi; Tsuruo, Yoshihiro; Sata, Masataka
• Publication, Distribution, etc.: Japanese Circulation Society
• Publication Date: 2020-04-24
• Publication Date (W3CDTF): 2020-04-24
• Alternative Title: 未固定遺体における動脈硬化性冠動脈プラークと冠動脈外膜vasa vasorum及び局所心臓周囲脂肪内炎症との関連; Coronary Plaque and Epicardial Adipose Inflammation
• Periodical title: Circulation Journal
• No. or year of volume/issue: 84 5
• Volume: 84
• Issue: 5
• Pages: 769-775
• ISSN (Periodical Title): ISSN : 1347-4820
• Degree grantor/type: 徳島大学
• Date Granted: 2021-12-23
• Dissertation Number: 甲第3564号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Coronary plaque; Epicardial adipose tissue; Fresh cadaver; Inflammatory molecules; Vasa vasorum
• Target Audience: 一般
• Note (General): Background: The coronary adventitia has recently attracted attention as a source of inflammation because it harbors nutrient blood vessels, termed the vasa vasorum (VV). This study assessed the link between local inflammation in adjacent epicardial adipose tissue (EAT) and coronary arterial atherosclerosis in fresh cadavers. Methods and Results: Lesion characteristics in the left anterior descending coronary artery of 10 fresh cadaveric hearts were evaluated using integrated backscatter intravascular ultrasound (IB-IVUS), and the density of the VV and levels of inflammatory molecules from the adjacent EAT were measured for each of the assessed lesions. The lesions were divided into lipid-rich, lipid-moderate, and lipid-poor groups according to percentage lipid volume assessed by IB-IVUS. Higher expression of inflammatory molecules (i.e., vascular endothelial growth factor A [VEGFA] and VEGFB) was observed in adjacent EAT of lipid-rich (n=11) than in lipid-poor (n=11) lesions (7.99±3.37 vs. 0.45±0.85 arbitrary units [AU], respectively, for VEGFA; 0.27±0.15 vs. 0.11±0.07 AU, respectively, for VEGFB; P<0.05). The density of adventitial VV was greater in lipid-rich than lipid-poor lesions (1.50±0.58% vs. 0.88±0.23%; P<0.05). Conclusions: Lipid-rich coronary plaques are associated with adventitial VV and local inflammation in adjacent EAT in fresh cadavers. This study suggests that local inflammation of EAT is associated with coronary plaque progression via the VV.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1253/circj.CJ-19-0914
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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